Neuro-gliovascular module of the corpus callosum in the diagnosis of diffuse axonal brain injury
- Authors: Koludarova E.M.1, Zorikov O.V.1, Tuchik E.S.1,2
-
Affiliations:
- Russian Centre of Forensic Medical Expertise, Ministry of Health of the Russia
- The Russian National Research Medical University named after N.I. Pirogov
- Issue: Vol 6, No 4 (2020)
- Pages: 30-34
- Section: ORIGINAL STUDY ARTICLES
- URL: https://journals.rcsi.science/2411-8729/article/view/122412
- DOI: https://doi.org/10.19048/fm336
- ID: 122412
Cite item
Full Text
Abstract
Background: Currently, there is no scientifically based diagnostic complex for diffuse axonal brain injury (DAI) which allows to reveal its morphological substrate and determine the time elapsed after it, especially in the early post-traumatic period.
Aims: The aim of the study was to identify of morphological changes in the corpus callosum in various post-traumatic periods after DAI. The material of the study is the corpus callosum of victims who died from traumatic brain injury with DAI within the first hour (group I, n=25), in the period from 1 to 12 hours (group II, n=30) and in the period from 12 to 48 hours (group III, n=17) before the death. The control group of the study comprises the corpus callosum (n=25) of those who died from various causes of non-violent and violent death (without any head trauma).
Results: The main diagnostic criterion for DAI is represented by hemorrhages in the substance of the corpus callosum truncus. The proposed complex of morphological changes in the neuro-gliovascular module will allow to determine the time elapsed after DAI.
Conclusions: DAI as a special type of traumatic brain injury is manifested by a pathognomonic complex of pathomorphological changes in the deep structures of the brain, including the corpus callosum. Objectification of the time elapsed after DAI should be based on a comparative assessment of all morphological features of the identified neuro-gliovascular module, while its individual features can not be considered as diagnostic.
Full Text
##article.viewOnOriginalSite##About the authors
Ekaterina M. Koludarova
Russian Centre of Forensic Medical Expertise, Ministry of Health of the Russia
Author for correspondence.
Email: koludarova@rc-sme.ru
ORCID iD: 0000-0003-1989-7789
SPIN-code: 5593-7492
Сandidate of Мedical Sciences, Forensic medical expert
Russian Federation, 12/13 bld, Polikarpova str., 125284, MoscowOleg V. Zorikov
Russian Centre of Forensic Medical Expertise, Ministry of Health of the Russia
Email: zorikov@rc-sme.ru
ORCID iD: 0000-0002-1396-7881
SPIN-code: 2215-6701
Forensic medical expert
Russian Federation, MoscowEvgeny S. Tuchik
Russian Centre of Forensic Medical Expertise, Ministry of Health of the Russia; The Russian National Research Medical University named after N.I. Pirogov
Email: tuchik@rc-sme.ru
ORCID iD: 0000-0003-4330-2327
SPIN-code: 1290-0060
Doctor of Medical Sciences, Professor, Department of Forensic Medicine; Head of the Organizational and methodological Department
Russian Federation, Moscow; MoscowReferences
- Koludarova EM, Tuchik ES. Aspects of postmortem diagnosis of diffuse axonal injury of the brain. Bulletin of forensic medicine. 2019;8(3):44–49. (In Russ.)
- Romodanovskii PO. Kompleksnaya sudebno-meditsinskaya diagnostika i ehkspertnaya otsenka povrezhdenii golovnogo mozga pri travme golovy [dissertation abstract]. Moscow; 1996. Available from: https://search.rsl.ru/ru/record/01000041957. (In Russ.)
- Su E, Bell M. Diffuse Axonal Injury. In: Laskowitz D, Grant G. Translational Research in Traumatic Brain Injury. Boca Raton (FL): CRC Press/Taylor and Francis Group; 2016. 436 р. doi: 10.1201/b18959
- Geddes JF, Whitwell HL, Graham DI. Traumatic axonal injury: Practical issues for diagnosis in medicolegal cases. Neuropathol Appl Neurobiol. 2000;26:105–116. doi: 10.1046/j.1365-2990.2000.026002105.x
- Barros CS, Franco SJ, Muller U. Extracellular matrix: Functions in the nervous system. Cold Spring Harbor Perspectives in Biology. 2011;3(1):a005108. doi: 10.1101/cshperspect.a005108
- Maxwell WL. Development of concepts in the pathology of traumatic axon and traumatic brain injuryю In: Kobeissy FH. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects (Frontiers in Neuroengineering Series). Boca Raton (FL): CRC Press/Taylor and Francis Group; 2015. 725 р.