Mammaglobin mRNA expression as early breast cancer marker

V Konstantinovich Bojenko; Боженко Владимир Константинович; V Alekseevich Solodky; Солодкий Владимир Алексеевич; N Vladimirovna Kharchenko; Харченко Наталья Владимировна; I Dmitrievich Trotsenko; Троценко Иван Дмитриевич; D Yur'evich Trofimov; Трофимов Дмитрий Юрьевич; E Aleksandrovna Kudinova; Кудинова Елена Александровна; E Fedorovna Vaskevich; Васкевич Елена Федоровна; O V Burmenskaya; Бурменская Ольга Владимировна

Mammaglobin mRNA expression as early breast cancer marker

Авторлар: Bojenko VK.¹, Solodky VA.¹, Kharchenko NV.², Trotsenko ID.², Trofimov DY.³, Kudinova EA.¹, Vaskevich EF.¹, Burmenskaya OV⁴
Мекемелер:
1. Scientific Center of Roentgenoradiology of RAMS
2. People’s Friendship University of Russia
3. “DNA Technology”
4. Research Center for Obstetrics, Gynecology and Perinatology
Шығарылым: № 2 (2013)
Беттер: 71-77
Бөлім: Articles
URL: https://journals.rcsi.science/2313-0245/article/view/337166
ID: 337166

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Аннотация

Early breast cancer (BC) diagnosis is a basis for overall and relapse-free survival improvement. But methods of X-ray and morphological examination sometimes are failed in BC diagnosis. New molecular markers may give more information about BC progression. One of these markers is mammaglobin. We studied 114 tissue samples: 57 I—IV stages BC samples and 57 samples of morphologically normal breast tissue (MNBT). mRNA mammaglobin expression was assessed by qPCR with reverse transcription. mRAN mammaglobin expression was significantly higher in BC samples as compared to MNBT (p = 0,0019), besides expression level decreased during BC progression: minimal level in T3 (p = 0,0338), grade 3 (p = 0,037) and stage IV (p = 0,035) tumors. hMAM expression correlated with steroid receptors (estrogen receptor, progesterone receptpor) in MNBT (p < 0.05), but not in BC tissue. hMAM mRNA expression decreased during BC progression and correlated with steroid receptors in MNBT. hMAM expression profiling may be used as a marker in BC diagnosis.

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breast cancer, tumor progression, hMAM expression, mammaglobin, uteroglobin

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Mammaglobin mRNA expression as early breast cancer marker

Толық мәтін

Аннотация

Негізгі сөздер

Авторлар туралы

V Bojenko

V Solodky

N Kharchenko

I Trotsenko

D Trofimov

E Kudinova

E Vaskevich

O Burmenskaya

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