STUDY FOR ANTIMYCOBACTERIAL ACTIVITY OF PYATD10 DIAZINON DERIVATIVE

We have carried out the analysis of antymicobacterial activity of PYATd10 dia- zinon derivative and dapsone. The capability of PYATd10 compound and dapsone drug to suppress the growth of M.lufu culture was studied by the method of serial dilutions. Vis- ual evaluation of inoculations in medium Shkolnikova showed that there was no growth of mycobacteria with PYATd10 concentration 128 µg/ml, while minimum suppressing con- centration of dapsone were equal to 32 µg/ml. Examining smears, colored according to Mu- rohashi, under the influence of PYATd10 ex- cipient and dapsone drug in the same concen- trations, we have revealed the decrease of my- cobacterial living forms content. A share of inviable bacteria decreased after the cultiva- tion intensification, but amounts to less than 35%. Thus, the PYATd10 compound exhibits antimycobacterial activity towards M. lufu, being slightly inferior to the dapsone compara- tive drug by this type of activity.

M.lufu, diazinone derivatives, dapsone, M. lufu, antileprotic activity