Mumps: achievements, problems and ways of solution

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Abstract

The aim. The article highlights the current state of the problem of mumps in the world and the Russian Federation.

Materials and methods. The materials of the study were electronic resources WHO infection control, Cohrane, Elsevier, ScienceDirect, CDC infection diseases database, PubMed, eLibrary, CyberLeninka. The research methods were the analysis and generalization of scientific literature. The assessment is presented by the immunological structure of the population in different age groups to mumps (n = 593) in the study area (2018) according to the data of the Center for Hygiene and Epidemiology in the Perm Territory.

Results. The spread of mumps is found to be widespread and uneven in different regions of the world in the form of sporadic cases and large epidemic outbreaks, despite the world practice of vaccine prevention of mumps. Analysis of the immunological structure to mumps in different age groups revealed a fairly high number of seronegative individuals (the largest number was found among adults aged 20–39 years) in the study area (2018). A decrease in the tension of post-vaccination immunity is the main cause for the emergence of an outbreak among the adult population, in addition to vaccination failures among vaccinated children. The immune defenses created by the vaccine strain do not have the same intensity and duration as with natural infection, and some genotypes of “wild” variants of the mumps virus can break through the immune barrier and cause disease. Antigenic differences between vaccine and circulating strains, low inoculation dose can weaken immunity and reduce the effectiveness of mass vaccine prevention.

Conclusion. Ways of solving the problem were proposed to forestall an unfavorable epidemic situation with mumps.

About the authors

Vadislav V. Semerikov

Perm State Medical University named after academician E.А.Wagner

Author for correspondence.
Email: metodkkib1@yandex.ru
ORCID iD: 0000-0002-5346-8104

Doctor of Sciences (Medicine), Professor of the Department of Epidemiology and Hygiene

Russian Federation, 26, Petropavlovsk st., Perm, 614990

Nadezhda V. Yuminova

Research Institute of Vaccines and Sera named after I.I. Mechnikov

Email: yuminova@mail.ru
ORCID iD: 0000-0002-7723-4038

Doctor of Sciences (Biology), Associate Professor, the Head of the Laboratory of Pediatric Viral Infections

Russian Federation, 5а, Maly Kazenny lane, Moscow, 105064

Nina O. Postanogova

Perm State Medical University named after academician E.А.Wagner

Email: nina40000@yandex.ru
ORCID iD: 0000-0003-0559-1914

assistant of Department of Pediatrics with a course of outpatient pediatrics

Russian Federation, 26, Petropavlovsk st., Perm, 614990

Ludmila V. Sofronova

Perm State Medical University named after academician E.А.Wagner

Email: pediatr-17@mail.ru
ORCID iD: 0000-0001-5524-8191

Doctor of Sciences (Medicine), Professor of the Department of Pediatrics with a course of outpatient pediatrics

Russian Federation, 26, Petropavlovsk st., Perm, 614990

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Supplementary files

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2. Figure 1 – The structure of the mumps virus according to N. Litusov, 2018 [13]

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3. Figure 2 – Dynamics of the incidence of mumps in the Russian Federation (in terms of per 100 thousand population)

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Copyright (c) 2020 Semerikov V.V., Yuminova N.V., Postanogova N.O., Sofronova L.V.

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