Adrenomedullin is a biological marker of heart failure: review of modern literature Amina M. Alieva*1, Natalia
- 作者: Alieva A.1, Teplova N.1, Voronkova K.1, Pinchuk T.1, Valiev R.2, Shnakhova L.3, Rahaev A.4, Nikitin I.1
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隶属关系:
- Pirogov Russian National Research Medical University
- Loginov Moscow Clinical Scientific Center
- Sechenov First Moscow State Medical University (Sechenov University)
- Main Bureau of Medical and Social Expertise in the Kabardino-Balkarian Republic
- 期: 卷 13, 编号 1 (2022)
- 页面: 64-69
- 栏目: Reviews
- URL: https://journals.rcsi.science/2221-7185/article/view/109543
- DOI: https://doi.org/10.17816/22217185.2022.1.201472
- ID: 109543
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It has been proven that in patients with heart failure (HF), there is an increased level of adrenomedullin (ADM) in plasma. Biomarker indices correlate with the severity of hemodynamic dysfunction, as well as with neurohumoral indices, which are activated depending on the severity of congestive circulatory failure. In addition, the expression of the ADM gene in the heart and kidneys is increased in experimental and clinical HF. A small number of studies have examined the effect of ADM infusion. These studies have generally shown that hormone infusion has beneficial hemodynamic effects and promotes the maintenance/improvement of renal function, but most of the studies have been short-lived. The available results suggest that increasing ADM levels reduce the negative effects of vasoconstriction and sodium retention. A better understanding of the role of a biological marker in congestive circulatory failure may lead to the development of drugs that target ADM receptors.
作者简介
Amina Alieva
Pirogov Russian National Research Medical University
编辑信件的主要联系方式.
Email: amisha_alieva@mail.ru
ORCID iD: 0000-0001-5416-8579
Cand. Sci. (Med.)
俄罗斯联邦, MoscowNatalia Teplova
Pirogov Russian National Research Medical University
Email: amisha_alieva@mail.ru
ORCID iD: 0000-0002-7181-4680
D. Sci. (Med.), Prof.
俄罗斯联邦, MoscowKira Voronkova
Pirogov Russian National Research Medical University
Email: amisha_alieva@mail.ru
D. Sci. (Med.)
俄罗斯联邦, MoscowTatyana Pinchuk
Pirogov Russian National Research Medical University
Email: amisha_alieva@mail.ru
ORCID iD: 0000-0002-7877-4407
Cand. Sci. (Med.)
俄罗斯联邦, MoscowRamiz Valiev
Loginov Moscow Clinical Scientific Center
Email: amisha_alieva@mail.ru
ORCID iD: 0000-0003-1613-3716
Cand. Sci. (Med.)
俄罗斯联邦, MoscowLidia Shnakhova
Sechenov First Moscow State Medical University (Sechenov University)
Email: amisha_alieva@mail.ru
ORCID iD: 0000-0003-3000-0987
therapist
俄罗斯联邦, MoscowAlik Rahaev
Main Bureau of Medical and Social Expertise in the Kabardino-Balkarian Republic
Email: amisha_alieva@mail.ru
ORCID iD: 0000-0001-9601-1174
D. Sci. (Med.), Main Bureau of Medical and Social Expertise in the Kabardino-Balkarian Republic
俄罗斯联邦, NalchikIgor Nikitin
Pirogov Russian National Research Medical University
Email: amisha_alieva@mail.ru
ORCID iD: 0000-0003-1699-0881
D. Sci. (Med.), Prof.
俄罗斯联邦, Moscow参考
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