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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">CardioSomatics</journal-id><journal-title-group><journal-title xml:lang="en">CardioSomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>CardioСоматика</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2221-7185</issn><issn publication-format="electronic">2658-5707</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">96366</article-id><article-id pub-id-type="doi">10.17816/22217185.2021.4.201062</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Type 2 diabetes mellitus and chronic heart failure: new treatment strategies</article-title><trans-title-group xml:lang="ru"><trans-title>Сахарный диабет 2-го типа и хроническая сердечная недостаточность: новые стратегии лечения</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5178-6029</contrib-id><name-alternatives><name xml:lang="en"><surname>Bondarenko</surname><given-names>Irina Z.</given-names></name><name xml:lang="ru"><surname>Бондаренко</surname><given-names>Ирина Зиятовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>д-р мед. наук, гл. науч. сотр. отд. кардиологии, эндоваскулярной и сосудистой хирургии</p></bio><email>iz_bondarenko@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2250-5942</contrib-id><name-alternatives><name xml:lang="en"><surname>Bubnova</surname><given-names>Marina G.</given-names></name><name xml:lang="ru"><surname>Бубнова</surname><given-names>Марина Геннадьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.), Prof.</p></bio><bio xml:lang="ru"><p>д-р мед. наук, проф., рук. отд. реабилитации и вторичной профилактики сердечно-сосудистых заболеваний</p></bio><email>iz_bondarenko@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Endocrinology Research Centre</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр эндокринологии» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">National Research Center for Therapy and Preventive Medicine</institution></aff><aff><institution xml:lang="ru">ФГБОУ «Национальный медицинский исследовательский центр терапии и профилактической медицины» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2021</year></pub-date><volume>12</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>234</fpage><lpage>238</lpage><history><date date-type="received" iso-8601-date="2022-01-13"><day>13</day><month>01</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-01-13"><day>13</day><month>01</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, ООО "Эко-Вектор"</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.rcsi.science/2221-7185/article/view/96366">https://journals.rcsi.science/2221-7185/article/view/96366</self-uri><abstract xml:lang="en"><p>The article is devoted to the use of sodium-glucose cotransporter type 2 inhibitors in patients with type 2 diabetes mellitus and chronic heart failure drawing the example of clinical studies with Empagliflozin. Key results of the clinical studies are considered, thanks to which it can be argued that patients with type 2 diabetes mellitus and atherosclerosis-associated diseases, including chronic heart failure, have advantages in predicting cardiovascular outcomes when using hypoglycemic drugs and adding Empagliflozin to standard cardiovascular therapy.</p></abstract><trans-abstract xml:lang="ru"><p>Статья посвящена применению ингибиторов натрий-глюкозного котранспортера 2-го типа у пациентов с сахарным диабетом 2-го типа и хронической сердечной недостаточностью на примере клинических исследований с эмпаглифлозином. Освещены ключевые результаты исследований, благодаря которым можно утверждать, что больные сахарным диабетом 2-го типа и заболеваниями, ассоциированными с атеросклерозом, в том числе с хронической сердечной недостаточностью, имеют преимущества в прогнозе сердечно-сосудистых исходов на фоне сахароснижающей терапии, дополнительного назначения эмпаглифлозина к стандартной сердечно-сосудистой терапии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>diabetes mellitus</kwd><kwd>chronic heart failure</kwd><kwd>hypoglycemic therapy</kwd><kwd>empagliflozin</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>сахарный диабет</kwd><kwd>хроническая сердечная недостаточность</kwd><kwd>сахароснижающая терапия</kwd><kwd>эмпаглифлозин</kwd></kwd-group><funding-group><award-group><funding-source><institution-wrap><institution xml:lang="ru">Берингер Ингельхайм</institution></institution-wrap><institution-wrap><institution xml:lang="en">Boehringer Ingelheim</institution></institution-wrap></funding-source></award-group></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Nichols GA, Hillier TA, Erbey JR, Brown JB. 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