Evolution of Exons and the Exon–Intron Structure of Long Intergenic Noncoding RNA Genes in Placental Mammals
- Авторлар: Sidorenko I.1, Rogozin I.1,2, Babenko V.1,3
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Мекемелер:
- Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences (SB RAS)
- National Institute of Health, Rockville Pike
- Novosibirsk State University
- Шығарылым: Том 9, № 6 (2019)
- Беттер: 491-502
- Бөлім: Article
- URL: https://journals.rcsi.science/2079-0864/article/view/207097
- DOI: https://doi.org/10.1134/S2079086419060069
- ID: 207097
Дәйексөз келтіру
Аннотация
Long intergenic noncoding RNA (lincRNA) genes are abundant in mammals, but their functions remain elusive. The characteristics of lincRNAs can be studied via comparative analysis with those of mRNAs, for which there is a wealth of information. Highly conserved coding sequences (exons) and the exon–intron structure are some typical evolutionary features attributed to eukaryotic mRNAs. The exon structure is conserved considerably less in lincRNA, but to a greater degree than for introns. Comparative analysis of putative intron positions in lincRNA genes in a range of mammalian genomes underscored the high positional conservation for some introns, which appear to be up to 100 million years old. It is therefore possible that primary and/or secondary structure of these molecules confers functional signals.
Негізгі сөздер
Авторлар туралы
I. Sidorenko
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences (SB RAS)
Email: vl_babenko@yahoo.com
Ресей, Novosibirsk, 630090
I. Rogozin
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences (SB RAS); National Institute of Health, Rockville Pike
Email: vl_babenko@yahoo.com
Ресей, Novosibirsk, 630090; Bethesda, MD, 20892
V. Babenko
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences (SB RAS); Novosibirsk State University
Хат алмасуға жауапты Автор.
Email: vl_babenko@yahoo.com
Ресей, Novosibirsk, 630090; Novosibirsk, 630090