Clinical markers for unfavorable course of multiple sclerosis
- 作者: Matrosova M.1, Belskaya G.1, Bryukhov V.1, Popova E.2,3, Krotenkova M.1
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隶属关系:
- Research Center of Neurology
- City Clinical Hospital No. 24, Moscow
- Pirogov Russian National Research Medical University
- 期: 卷 17, 编号 3 (2023)
- 页面: 41-48
- 栏目: Original articles
- URL: https://journals.rcsi.science/2075-5473/article/view/253956
- DOI: https://doi.org/10.54101/ACEN.2023.3.5
- ID: 253956
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详细
Objective. To study possible clinical markers associated with the unfavorable course of multiple sclerosis and its transition to a progressive subtype.
Materials and methods. This prospective study included healthy volunteers and patients with relapsing-remitting multiple sclerosis (RRMS), secondary progressive multiple sclerosis (SPMS), primary progressive multiple sclerosis (PPMS). For a comprehensive clinical evaluation, the participants completed the Timed 25-Foot Walk Test (T25-FW), Nine-Hole Peg Test (9-HPT), Symbol Digit Modalities Test (SDMT), Fatigue test, and MSProDiscuss questionnaires. Then we compared the results between the groups.
Results. We found significant differences between the groups in regard to most of the tests. Furthermore, we proposed a composite clinical score (CCS) based on T25-FW, SDMT, and 9-HPT results (for both hands).
Discussion. Our CCS can be a useful clinical tool to determine the most likely course of multiple sclerosis at a certain timepoint.
作者简介
Mariya Matrosova
Research Center of Neurology
编辑信件的主要联系方式.
Email: matrosova@neurology.ru
ORCID iD: 0000-0003-4604-7288
SPIN 代码: 4322-6488
radiologist, PhD student, Research Center of Neurology, Moscow, Russia
俄罗斯联邦, MoscowGalina Belskaya
Research Center of Neurology
Email: belskaya@neurology.ru
ORCID iD: 0000-0001-9831-8970
D. Sci. (Med.), Professor, Head, Multidisciplinary clinical and diagnostic center, Research Center of Neurology, Moscow, Russia
俄罗斯联邦, MoscowVasiliy Bryukhov
Research Center of Neurology
Email: abdomen@rambler.ru
ORCID iD: 0000-0002-1645-6526
SPIN 代码: 6299-3604
Cand. Sci. (Med.), radiologist, senior researcher, Research Center of Neurology, Moscow, Russia
俄罗斯联邦, MoscowEkaterina Popova
City Clinical Hospital No. 24, Moscow; Pirogov Russian National Research Medical University
Email: matrosova@neurology.ru
ORCID iD: 0000-0003-2676-452X
D. Sci. (Med.), Head, Multiple sclerosis сenter, City Clinical Hospital No. 24, Moscow, Russia; Assoc. Prof., Department of neurology, neurosurgery and medical genetics, Pirogov Russian National Research Medical University, Moscow, Russia
俄罗斯联邦, Moscow; MoscowMarina Krotenkova
Research Center of Neurology
Email: krotenkova_mrt@mail.ru
ORCID iD: 0000-0003-3820-4554
SPIN 代码: 9663-8828
D. Sci. (Med.), main researcher, Head, Department of radiology, Research Center of Neurology, Moscow, Russia
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