Mood Disorders After COVID-19

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Introduction. The COVID-19 pandemic has led to a high prevalence of post-COVID-19 syndrome (PCS), with mood disorders being the most common manifestations.

Objective: To study the prevalence of PCS-associated mood disorders and their features.

Materials and methods. We examined patients after COVID-19 (n = 91; age: 24-84 years; median time to recovery: 7 months) using the following tools: the BDI and HADS (screening for anxiety and depression); the Starkstein Apathy Scale; FIS and FSS (fatigue assessment); the MoCA, MMSE, and FAB (cognitive assessment); the FIRST, ESS, PSQI, and ISI (sleep disorders evaluation); the EQ5D (quality of life measurement). We designed a special questionnaire to collect data related to a history of COVID-19 and patients' condition after discharge. In addition, we analyzed electronic medical records and discharge summaries and performed neurological examination.

Results. Of all the examined patients, 65 (71.4%) participants had signs and symptoms of PCS. Mood disorders were observed in 33 (50.8%) cases, with apathy (78.7%), anxiety (66.7%), and fatigue (60.6%) being the most common. Depressive disorders were found in 12 (36.3%) patients. Cognitive functions were impaired in 7 (21.2%) patients; sleep disorders were observed in 16 (48.5%) cases. We found a positive correlation between depressive disorders and fatigue based on the BDI, FIS, and FSS scores (rS = 0.711; rS = 0.453), depressive disorders and anxiety (rS = 0.366), fatigue and apathy (rS = 0.350). Anxiety increased the risk of sleep disorders (rS = 0.683). Quality of life has been shown to decrease in patients with mood disorders due to the negative effect of long-term fatigue and depressive disorders.

Conclusions. There is a close connection between different types of mood disorders that develop after COVID-19 and exacerbate symptoms of each other. Early diagnosis and treatment of these disorders can improve patients' quality of life and preserve their ability to work.

作者简介

Anna Mikheeva

Almazov National Medical Research Centre

编辑信件的主要联系方式.
Email: amikheevag@mail.ru
ORCID iD: 0000-0002-1478-6580

Postgraduate Student, Department of Neurology with the Clinic, Medical Education Institute, Laboratory Assistant-Researcher, Research Laboratory of New Coronavirus Infection and Postcovid Syndrome, Center for Personalized Medicine

俄罗斯联邦, St. Petersburg

Mariya Topuzova

Almazov National Medical Research Centre

Email: Topuzova_MP@almazovcentre.ru
ORCID iD: 0000-0002-0175-3085

Cand. Sci. (Med.), Associate Professor, Department of Neurology with the Clinic, Medical Education Institute, Senior Researcher, Research Laboratory of New Coronavirus Infection and Postcovid Syndrome, Center for Personalized Medicine

俄罗斯联邦, St. Petersburg

Valeriya Malko

Almazov National Medical Research Centre

Email: Malko_VA@almazovcentre.ru
ORCID iD: 0000-0003-2230-3750

Postgraduate Student, Department of Neurology with the Clinic, Medical Education Institute, Junior Researcher, Research Laboratory of New Coronavirus Infection and Postcovid Syndrome, Center for Personalized Medicine

俄罗斯联邦, St. Petersburg

Ekaterina Zhilina

Almazov National Medical Research Centre

Email: Zhilina_ES@almazovcentre.ru
ORCID iD: 0000-0002-9020-3287

Resident, Department of Neurology with the Clinic, Medical Education Institute

俄罗斯联邦, St. Petersburg

Arina Mikhailova

Almazov National Medical Research Centre

Email: Mikhailova_AA@almazovcentre.ru
ORCID iD: 0000-0001-6066-3525

Laboratory Research Assistant, Research Laboratory of New Coronavirus Infection and Postcovid Syndrome, Center for Personalized Medicine, Resident, Department of Endocrinology

俄罗斯联邦, St. Petersburg

Daria Lagutina

Almazov National Medical Research Centre

Email: Lagutina_DI@almazovcentre.ru
ORCID iD: 0000-0001-6198-5278

Laboratory Research Assistant, Research Laboratory of New Coronavirus Infection and Postcovid Syndrome, Center for Personalized Medicine, Resident, Department of Endocrinology

俄罗斯联邦, St. Petersburg

Tatiana Karonova

Almazov National Medical Research Centre

Email: Karonova_TL@almazovcentre.ru
ORCID iD: 0000-0002-1547-0123

D. Sci. (Med.), Head, Research Laboratory of New Coronavirus Infection and Postcovid Syndrome, Center for Personalized Medicine, Chief Researcher, Clinical Endocrinology Laboratory, Professor, Department of Internal Medicine

俄罗斯联邦, St. Petersburg

Tatyana Alekseeva

Almazov National Medical Research Centre

Email: Alekseeva_TM@almazovcentre.ru
ORCID iD: 0000-0002-4441-1165

D. Sci. (Med.), Head, Department of Neurology with the Clinic, Medical Education Institute

俄罗斯联邦, St. Petersburg

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