Venous thrombogenesis and functional state of the hemorheology and hemostasis system in stroke patients


如何引用文章

全文:

详细

Comparison of the results of investigation of the hemorheology and hemostasis system in patients with stroke of various types, localization, and severity who were treated at critical and intensive care units, with venous thromboembolic complications (VTECs) and without VTEC, demonstrated a high significance of impairments in the hemorheology and hemostasis system for VTEC pathogenesis in stroke patients. Despite ongoing anticoagulant therapy, aggravation of the prothrombogenic state was observed in VTEC patients. Ischemic stroke was associated with more severe changes compared to hemorrhagic stroke. Hemostasiological predictors of VTEC were identified. In patients without VTEC, both the coagulation and anticoagulation systems as well as the fibrinolysis system were preserved. The D-dimer and thrombophilia markers, such as hyperhomocysteinemia and antiphospholipid syndrome, were shown not to contribute to the development of VTEC in stroke patients.

作者简介

Yulia Ryabinkina

Research Center of Neurology

编辑信件的主要联系方式.
Email: ryabinkina11@mail.ru
ORCID iD: 0000-0001-8576-9983

D. Sci. (Med.), Head, Intensive critical care department

俄罗斯联邦, 125367 Moscow, Volokolamskoye shosse, 80

Mikhail Piradov

Research Center of Neurology

Email: ryabinkina11@mail.ru
ORCID iD: 0000-0002-6338-0392

D. Sci. (Med.), Professor, Full Member of the Russian Academy of Sciences, Director

俄罗斯联邦, Moscow

Marine Tanashyan

Research Center of Neurology

Email: ryabinkina11@mail.ru
ORCID iD: 0000-0002-5883-8119

D. Sci. (Med.), Prof., Corresponding member of RAS, Deputy Director for science, Head, 1st Neurological department

俄罗斯联邦, Moscow

Alla Shabalina

Research Center of Neurology

Email: ryabinkina11@mail.ru
ORCID iD: 0000-0001-9604-7775

D. Sci. (Med.), leading researcher, Head, Laboratory of hemorheology, hemostasis and pharmacokinetics (with clinical laboratory diagnostics)

俄罗斯联邦, Moscow

M. Kostyreva

Research Center of Neurology

Email: ryabinkina11@mail.ru
俄罗斯联邦, Moscow

参考

  1. Верещагин Н.В., Пирадов М.А. Принципы ведения и лечения больных в острейший период инсульта. Вестник интенсивной терапии.1997;1–2:35.
  2. Пирадов М.А., Гулевская Т.С., Гнедовская Е.В., Рябинкина Ю.В. Синдром полиорганной недостаточности при тяжелых формах инсульта (клинико-морфологическое исследование). Неврологич. журнал, 2006; 5: 9–13.
  3. Российские клинические рекомендации по диагностике, лечению и профилактике венозных тромбоэмболических осложнений. Флебология, 2010;1: 2: 3–28.
  4. Рябинкина Ю.В., Гнедовская Е.В., Максимова М.Ю. и др. Инсульт: частота развития и факторы риска венозных тромбоэмболических осложнений в условиях отделения реанимации и интенсивной терапии. Анестезиология и реаниматология, 2015; 5: 54–59.
  5. Стойко Ю.М., Замятин М.Н. Современные возможности профилактики тромбоэмболических осложнений у пациентов с высоким и очень высоким риском.Consilium Medicum. Хирургия, 2007; 2: 40–43.
  6. Пирадов М.А. Нейрореаниматология инсульта: состояние проблемы. Вестник Российской академии медицинских наук. 2003; 12: 68–70.
  7. Суслина З.А., Танашян М.М., Ионова В.Г. Ишемический инсульт: кровь, сосудистая стенка, антитромботическая терапия. М.: Медицинская книга, 2005.
  8. Andre C., de Freitas G.R., Fukujima M.M. Prevention of deep venous thrombosis and pulmonary embolism following stroke: a systematic review of published articles. Eur. J. Neurol.2007; 14: 21–32.
  9. Brandstater M.E., Roth E.J., Siebens H.C. Venous thromboembolism in stroke: literature review and implications for clinical practice. Arch Phys Med Rehabil.1992 May; 73 (5-S): 379–391.
  10. Field T.S. Hill Prevention of deep vein thrombosis and pulmonary embolism in patients with stroke. Clin. Appl. Thromb. Hemost., 2012; 18, 1: 5–19.
  11. Guidelines on the diagnosis and management of acute pulmonary embolism. The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). Eur. Heart J. 2008; 29: 2276–2315.
  12. Jauch E.C. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. E.C. Jauch, J.L. Saver, H.P. Adams Jr, A. Bruno, J.J. Connors, B.M. Demaerschalk, P. Khatri, P.W. McMullan Jr, A.I. Qureshi, K. Rosenfield, P.A. Scott, D.R. Summers, D.Z. Wang , M. Wintermark, H. Yonas. Stroke. 2013. 44 (3): 870–947.
  13. Kelly J., Rudd A., Lewis R., Hunt B.J. Venous thromboembolism after acute stroke. Stroke. 2001; 32 (1): 262–267.
  14. Rakesh P. et al. Burder of illness in venous thromboembolism in critical care: a multicenter observation study. Journal of Critical Care, 2005; 20: 341–347.
  15. Stroke Unit Trialists’ Collaboration. Organised inpatient (stroke unit) care for stroke Cochrane Database Syst Rev. –2007. 17(4). CD000197.PMID: 17943737.

版权所有 © Ryabinkina Y.V., Piradov M.A., Tanashyan M.M., Shabalina A.A., Kostyreva M.V., 2016

Creative Commons License
此作品已接受知识共享署名 4.0国际许可协议的许可
##common.cookie##