Expression of Pgp in cells of neurovascular unit in perinatal hypoxic-ischemic brain injury
- 作者: Morgun A.1, Taranushenko T.1, Malinovskaya N.1, Okuneva O.1, Ustinova S.1, Karpova L.1, Salmina A.1, Pozhilenkova E.1, Laletin D.1, Frolova O.1, Reusheva N.1, Trufanova L.1
-
隶属关系:
- Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
- 期: 卷 8, 编号 1 (2014)
- 页面: 40-43
- 栏目: Original articles
- URL: https://journals.rcsi.science/2075-5473/article/view/124618
- DOI: https://doi.org/10.17816/psaic192
- ID: 124618
如何引用文章
全文:
详细
We have studied peculiarities of P-glycoprotein (Pgp) expression on neuronal, astroglial and endothelial cells in newborn rats (P10) underwent perinatal hypoxic-ischemic brain damage. Expression of Pgp was markedly elevated in all the cells tested reaching the highest levels in astrocytes (4 hrs after injury) followed by increased levels in neuronal and endothelial cells (12 hrs after injury). The possible role of Pgp in pathogenesis of perinatal brain injury is discussed.
作者简介
A. Morgun
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
俄罗斯联邦, Krasnoyarsk
T. Taranushenko
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
俄罗斯联邦, Krasnoyarsk
N. Malinovskaya
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
俄罗斯联邦, Krasnoyarsk
O. Okuneva
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
俄罗斯联邦, Krasnoyarsk
S. Ustinova
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
俄罗斯联邦, Krasnoyarsk
L. Karpova
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
俄罗斯联邦, Krasnoyarsk
A. Salmina
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
俄罗斯联邦, Krasnoyarsk
E. Pozhilenkova
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
俄罗斯联邦, Krasnoyarsk
D. Laletin
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
俄罗斯联邦, Krasnoyarsk
O. Frolova
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
俄罗斯联邦, Krasnoyarsk
N. Reusheva
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
俄罗斯联邦, Krasnoyarsk
L. Trufanova
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
编辑信件的主要联系方式.
Email: reg.kgmu@gmail.com
俄罗斯联邦, Krasnoyarsk
参考
- Андрианов А.В., Моргун А.В., Таранушенко Т.Е., Салмина А.Б. Значение маркеров прогрессии при остеосаркомах у детей. Сибирск. онкологич. журн. 2008; 5: 37–40.
- Демко И.В., Салмина А.Б., Моргун А.В., Малиновская Н.А. Экспрессия Р-гликопротеина на лимфоцитах периферической крови при тяжелых формах бронхиальной астмы и его роль в определении чувствительности к терапии глюкокортикостероидам. Пульмонол. 2007; 3: 41–46.
- Моргун А.В., Таранушенко Т.Е., Салмина А.Б. Значение уровня экспрессии Р-гликопротеина при остеосаркомах у детей. Врач-аспирант 2006; 15: 519–524.
- Chan H.S., Grogan T.M., Haddad G. et al. P-glycoprotein expression: Critical determinant in the response to osteosarcoma chemotherapy. J. Natl. Cancer Inst. 1997; 89: 1706–1715.
- Gaillard P.J., Van Der Sandt I.C., Voorwinden L.H. et al. Astrocytes increase the functional expression of P-glycoprotein in an in vitro model of the blood-brain barrier. Pharm. Res. 2000; 17 (10): 1198–1205.
- Kuhnke D., Jedlitschky G., Grube M. et al. MDR1-P-glycoprotein (ABCB1) mediates transport of Alzheimer’s amyloid-ОІ peptides — Implications for the mechanisms of Aβ clearance at the blood-brain barrier. Brain Pathol. 2007; 17 (4): 347–353.
- Putman M., van Veen H.W., Konings W.N. Molecular properties of bacterial multidrug transporters. Microbiol. Mol. Biol. Rev. 2000; 64: 672–693.
- Ronaldson P.T., Bendayan M., Gingras D. et al. Cellular localization and functional expression of P-glycoprotein in rat astrocyte cultures. J. Neurochem. 2004; 3: 788–800.
- Salmina A.B., Inzhutova A.I., Malinovskaya N.A., Petrova M.M. Endothelial dysfunctions аnd repair in Alzheimer-type neurodegeneration: neuronal and glial control. J. Alzheimers Dis. 2010; 22 (1): 17–36.
- Sarkadi B., Homolya L., Szakacs G., Varadi A. Human multidrug resistance ABCB and ABCG transporters: Participation in a chemoimmunity defense system. Physiol. Rev. 2006; 86: 1179–1236.
- Volka H.A., Burkhardt K., Potschka H. et al. Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures. Neurosci. 2004; 123 (3): 751–759.
