Locomotion supraspinal control assessment in healthy people and stroke patients with the use of passive motor fMRI paradigm
- 作者: Kremneva E.1, Chernikova L.2, Konovalov R.1, Krotenkova M.1, Saenko I.3, Kozlovskaya I.3, Chervyakov A.1
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隶属关系:
- Research Center of Neurology
- Reseach Center of Neurology
- SSC RF Institute of blomedical problems, Russian Academy of Sciences
- 期: 卷 6, 编号 1 (2012)
- 页面: 31-40
- 栏目: Technologies
- URL: https://journals.rcsi.science/2075-5473/article/view/124508
- DOI: https://doi.org/10.17816/psaic281
- ID: 124508
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Functional magnetic resonance imaging (fMRI) is widely applicable for sensorimotor cortex mapping in human. The most challenging fMRI task for researchers is the assessment of locomotion. The aim of our study was to design of a passive motor fMRI paradigm for assess supraspinal control of the skillof walking in normal subjects and in patients with motor neurologic deficit after ischemic stroke. We conducted fMRI in two groups of human subjects: first group – 19 healthy subjects (10 females and 9 males, mean age = 38 [31,5; 60] years), second group – 18 ischemic stroke patients in early recovery period (first 6 months) (6 females, 12 males, mean age = 55,5 [45,5; 64,5] years) with severe and moderate (mean Fugl- Meyer scale score = 22 [15; 28]).The protocol consisted of blocked-design paradigm: plantar stimulation by imitation of slow walking vs rest. Individual and group activation patterns were analyzed using statistical package SPM5. A significant activation (pcorrect<0.05 at cluster level) in first group was observed in the primary and secondary sensorimotor cortex, premotor and dorsolateral prefrontal cortex, in insula. Due to lesion localization second group was subdivided into corticalsubcotrical (CS) and subcortical (S) subgroups. In CS subgroup there was reduce of activation size, more prominent in the affected hemisphere, whereas in S subgroup the extension of activation regions in both hemispheres was revealed, comparing to group 1. It was demonstrated that our passive motor fMRI paradigm of walking imitation with the use of plantar load imitator Korvit can be used to localize the ensorimotor brain areas involved in locomotion in both healthy people and patients. Concerning stroke patients, such an approach can help in understanding the mechanisms of supraspinal control of the skill walking and optimal rehabilitation strategy.
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作者简介
Elena Kremneva
Research Center of Neurology
编辑信件的主要联系方式.
Email: moomin10j@mail.ru
ORCID iD: 0000-0001-9396-6063
Cand. Sci. (Med.), senior researcher, Radiology department
俄罗斯联邦, 125367, Russia, Moscow, Volokolamskoye shosse, 80Lyudmila Chernikova
Reseach Center of Neurology
Email: moomin10j@mail.ru
俄罗斯联邦, Moscow
Rodion Konovalov
Research Center of Neurology
Email: moomin10j@mail.ru
ORCID iD: 0000-0001-5539-245X
Cand. Sci. (Med.), senior researcher, Neuroradiology department
俄罗斯联邦, 125367 Moscow, Volokolamskoye shosse, 80Marina Krotenkova
Research Center of Neurology
Email: moomin10j@mail.ru
ORCID iD: 0000-0003-3820-4554
D. Sci. (Med.), Head, Radiology department
俄罗斯联邦, 125367, Russia, Moscow, Volokolamskoye shosse, 80I. Saenko
SSC RF Institute of blomedical problems, Russian Academy of Sciences
Email: moomin10j@mail.ru
俄罗斯联邦, Moscow
I. Kozlovskaya
SSC RF Institute of blomedical problems, Russian Academy of Sciences
Email: moomin10j@mail.ru
俄罗斯联邦, Moscow
Alexander Chervyakov
Research Center of Neurology
Email: moomin10j@mail.ru
俄罗斯联邦, Moscow
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