Mechanisms of the development of skeletal muscle atrophy in chronic alcohol intoxication


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Chronic alcohol myopathy (CAM) is one of frequent manifestations of the alcoholic disease, but its pathogenesis remains to be elucidated. Main mechanism of the CAM development is suggested to be abnormalities of protein synthesis in muscle fibers. A complex clinical, morphological and biochemical investigation of 38 patients with chronic alcohol intoxication was performed. Clinical manifestations of skeletal muscle damage corresponded to severity of the atrophic process assessed by histological studies of muscle biopsies. Disturbances of main stages of protein synthesis both on intracellular and on systemic regulatory level was revealed.

 
 

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Yu. Kazantseva

1st Moscow State Medical University named after I.M. Sechenov

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Email: platonova@neurology.ru
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G. Maslova

1st Moscow State Medical University named after I.M. Sechenov

Email: platonova@neurology.ru
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E. Lysenko

Institute of Medico-Biological Problems, Russian Academy of Sciences (Moscow)

Email: platonova@neurology.ru
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O. Zinovyeva

1st Moscow State Medical University named after I.M. Sechenov

Email: platonova@neurology.ru
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B. Shenkman

Institute of Medico-Biological Problems, Russian Academy of Sciences (Moscow)

Email: platonova@neurology.ru
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N. Yakhno

1st Moscow State Medical University named after I.M. Sechenov

Email: platonova@neurology.ru
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版权所有 © Kazantseva Y.V., Maslova G.V., Lysenko E.A., Zinovyeva O.E., Shenkman B.S., Yakhno N.N., 2010

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