Results of the two-year treatment with avonex of 34 patients with relapsing remitting multiple sclerosis are summarized. This study provides evidence for the significant decrease in activity of the pathological process in patients treated with avonex, which is confirmed by the reduction of the relapse rate and the increase of the
proportion of patients remaining exacerbation-free. The decrease of the EDSS score has also been shown. In general, avonex was tolerated well in patients under study.
Results of the study of avonex efficiency in multiple sclerosis
- 作者: Peresedova A.1, Stoida N.1, Askarova L.1, Zakharova M.1, Adarcheva L.1, Niyazbekova A.1, Trifonova O.1, Rebrova O.1, Zavalishin I.1
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隶属关系:
- Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)
- 期: 卷 4, 编号 3 (2010)
- 页面: 20-24
- 栏目: Original articles
- URL: https://journals.rcsi.science/2075-5473/article/view/124452
- DOI: https://doi.org/10.17816/psaic335
- ID: 124452
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A. Peresedova
Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)
编辑信件的主要联系方式.
Email: platonova@neurology.ru
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N. Stoida
Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)
Email: platonova@neurology.ru
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L. Askarova
Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)
Email: platonova@neurology.ru
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M. Zakharova
Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)
Email: platonova@neurology.ru
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L. Adarcheva
Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)
Email: platonova@neurology.ru
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A. Niyazbekova
Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)
Email: platonova@neurology.ru
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O. Trifonova
Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)
Email: platonova@neurology.ru
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O. Rebrova
Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)
Email: platonova@neurology.ru
俄罗斯联邦
I. Zavalishin
Research Center of Neurology, Russian Academy of Medical Sciences (Moscow)
Email: platonova@neurology.ru
俄罗斯联邦
参考
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- Betaseron Efficacy Yielding Outcomes of New Dose (BEYOND). Press Release, Bayer Healthcare AG, October 29, 2007.
- Boster A., Racke M.K. Pharmacotherapy of multiple sclerosis: the PROOF trial. Expert Opin. Pharmacother. 2009; 10: 1235–1237.
- Clanet M., Radue E.W., Kappos L. et al. A randomized, doubleblind dose comparison study of weekly interferon beta-1a in relapsing MS. Neurology 2002; 59: 1507–1517.
- Comi G. Induction vs. escalating therapy in multiple sclerosis: practical implications. Neurol. Sci. 2008; 29 (Suppl. 2): 253–255.
- Freedman S.M. Dose response to interferon therapy in multiple sclerosis: an evaluation of the evidence. Curr. Med. Res. Opin. 2009; 25: 547–557.
- PRISMS Study Group. Randomized double-blind placebo-controlled study of interferon -1a in relapsing-remitting multiple sclerosis. Lancet 1998; 352: 1498–1504.
- Reynolds M.W., Stephen R., Seaman C., Rajagopalan K. Persistence and adherence to disease modifying drugs among patients with multiple sclerosis. Curr. Med. Res. Opin. 2010; 26: 663–674.
- The IFNB Multiple Sclerosis Study Group. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis: I. Clinical results of a multicentral, randomized double bind, placebo-controlled trial. Neurology 1993; 43: 655–661.
- Zidanov R., Locatelli L., Cookfair D. et al. Interferon beta-1a slows progression of brain atrophy in relapsing-remitting multiple sclerosis predominantly by reducing gray matter atrophy. Mult. Scler. 2007; 13: 490–501.
- Zidanov R., Munschauer F.E., Ramanathan M. et al. Clinical efficacy, effects on MRI and tolerability of weekly intramuscular interferon-beta-1a in patients with MS and CIS. Drugs Today 2008; 44: 601–613.
