Кортикальная реорганизация при рассеянном склерозе


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Аннотация

Функциональная магнитно-резонансная томография (фМРТ) является новым методом, способствующим изучению функций мозга и взаимоотношений между физиологической активностью и анатомической локализацией. В настоящее время реорганизация коры рассматривается как один из возможных факторов, обусловливающих улучшение или поддержание функции в случае необратимого повреждения мозга при рассеянном склерозе (РС). Функциональные кортикальные изменения коры были выявлены при всех фенотипах РС с использованием различных парадигм фМРТ, однако наиболее изучена двигательная система. Показана вариабельность функциональной реорганизации двигательной коры при РС в зависимости от стадии болезни. Кортикальная реорганизация играет роль в ограничении влияния структурных повреждений при РС; напротив, нарушение этих пластических механизмов может обусловливать развитие необратимого неврологического дефицита по мере прогрессирования болезни. Дальнейшие фМРТ-исследования в динамике позволят оценить изменения функциональной активности мозга при различной выраженности неврологического дефицита и различном характере регресса симптомов РС. Улучшение кортикальной адаптивной пластичности представляет собой потенциально значимое направление реабилитации больных РС.

Об авторах

I. A. Zavalishin

Научный центр неврологии РАМН, Москва

Автор, ответственный за переписку.
Email: platonova@neurology.ru
Россия

A. V. Peresedova

Научный центр неврологии РАМН, Москва

Email: platonova@neurology.ru
Россия

M. V. Krotenkova

Научный центр неврологии РАМН, Москва

Email: platonova@neurology.ru
Россия

O. V. Pugacheva

Научный центр неврологии РАМН, Москва

Email: platonova@neurology.ru
Россия

O. V. Trifonova

Научный центр неврологии РАМН, Москва

Email: platonova@neurology.ru
Россия

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© Zavalishin I.A., Peresedova A.V., Krotenkova M.V., Pugacheva O.V., Trifonova O.V., 2008

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