Influence of proton pump inhibitors on cognitive function and dementia risk

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Abstract

During the last half of the 20th century change of population age structure with constant increase of elderly and senior age population is observed all over the world. It determines the importance of prevention and treatment of great number of age-associated diseases including neurological ones. Proton pump inhibitors (PPI) use is one of possible risk factors for dementia and Alzheimer's disease development. The authors have performed research and data analysis on association of PPI use and dementia development. Acquired results are presented in the article. It has been shown that PPI use may influence b-amyloid production as they change b-secretase 1 and g-secretase activity - the enzymes responsible for b-amyloid precursor protein degradation, that results in increase of b-amyloid production. It was also demonstrated that cognitive impairment development in PPI use may be mediated by vitamin B12 deficit. Also the authors performed analysis of different PPI physical and chemical properties in order to develop suggestions on cognitive impairment risk decrease in patients with contributing risk factors. The performed analysis allowed to identify pantoprazole as one of the most appropriate medications for gastrointestinal disease treatment in patients with high risk of cognitive impairment and dementia development/progression.

About the authors

Olga D. Ostroumova

Pirogov Russian National Research Medical University - Russian Clinical and Research Center of Gerontology

Email: ostroumova.olga@mail.ru
D. Sci. (Med.), Full Prof. Moscow, Russia

Anton P. Pereverzev

Pirogov Russian National Research Medical University - Russian Clinical and Research Center of Gerontology

Email: acchirurg@mail.ru
Cand. Sci. (Med.) Moscow, Russia

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