Endothelial dysfunction in patients with chronic cerebral ischemia in atherosclerotic stenosis of the internal carotid arteries
- Authors: Starykh E.V1, Baranova O.A1, Tsoi I.V1
-
Affiliations:
- N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation
- Issue: Vol 19, No 2-2 (2017)
- Pages: 27-31
- Section: Articles
- URL: https://journals.rcsi.science/2075-1753/article/view/94671
- ID: 94671
Cite item
Full Text
Abstract
The aim of the study was to study endothelial function in patients with chronic cerebral ischemia in atherosclerotic stenosis of the internal carotid arteries (ICA). Materials and methods. A total of 69 patients were examined. Evaluation of the function of the endothelium was carried out using the photoplethysmographic method by the non-invasive diagnostic complex AngioScan-01 (Fiton). Along with this, a study was made of molecules of intercellular adhesion of VCAM and E-selectin. Results. Progression of neurological symptoms was revealed as the degree of stenosis of the internal carotid arteries increased, which was reflected in an increase in disorders of cranial nerves, motor, sensitive and autonomic systems. The increase in neurologic symptoms was accompanied by a decrease in the visco-elastic properties of the aorta, increased stiffness of large arteries, increased tonus of small resistive arteries and dysfunction of the endothelium in large and small muscle arteries. The highest values of E-selectin and vCAM were observed in patients with atherosclerotic lesions of the internal carotid arteries up to 30%. Conclusion. Violation of endothelial function in small resistive and in large conductive arteries is observed in patients with different degrees of stenosis of the ICA, starting with stenoses up to 30%. The processes of vascular inflammation are most pronounced at the initial stages of atherosclerotic stenosis of the ICA.
Full Text
##article.viewOnOriginalSite##About the authors
E. V Starykh
N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation
Email: starykh_elena@mail.ru
д-р мед. наук, проф. каф. неврологии ФГБОУ ВО «РНИМУ им. Н.И.Пирогова» 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1
O. A Baranova
N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation
Email: oabaranova@yandex.ru
канд. биол. наук, зав. учебной лаб. каф. неврологии ФГБОУ ВО «РНИМУ им. Н.И.Пирогова» 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1
I. V Tsoi
N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation
Email: irine.tsoy@mail.ru
аспирант каф. неврологии ФГБОУ ВО «РНИМУ им. Н.И.Пирогова», врач невролог неврологического отд-ния ЦКБ РАН 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1
References
- Куперберг Е.Б. Окклюзирующие поражения брахиоцефальных артерий (Клиника, ультразвуковая допплерография, ангиография). Автореф. дис.. канд. мед. наук. 1981; с. 2-24.
- Albers G.W, Caplan L.R, Easton J.D et al; TIA Working Group. Transient ischemic attack: proposal for a new definition. N Engl J Med 2002; 347: 1713-6.
- Moore W, Barnett H, Beebe H et al. Guidelines for carotid endarterectomy. A multidisciplinary consensus statement from the Ad Hoc Committee, American Heart Association. Circulation 1995; 91 (2): 566-79.
- Никифоров А.С., Коновалов А.Н., Гусев Е.И. Клиническая неврология. Учебник. Т. II. 2002; с. 54-5.
- Deredeyn C, Grubb R., Powers W. Cerebral hemodinamic impairment: methods of measurements and association with stroke risk. Neurology 1999; 53: 251-9.
- Schroeder Т. Hemodynamic significance of internal carotid artery disease. Acta Neurol Scand 1988; 77: 353-72.
- Швера И.Ю., Лишманов Ю.Б. Радионуклеидные методы исследования в оценке цереброваскулярного резерва. Ангиология и сосудистая хирургия. 1999; 5 (1): 63-71.
- Orosz L, Fulesdi В, Hoksbergen A et al. Assessment of cerebrovascular reserve capacity in asymptomatic and symptomatic hemodynamically significant carotid stenoses and occlusions. Surg Neurol 2002; 57 (5): 333-9.
- Кобалава Ж.Д. Основы превентивной терапии заболеваний, обусловленных атеросклерозом. Справ. практич. врача. 1996; 7: 10-2.
- Стулин И.Д. Ультразвуковые методы диагностики в неврологии. Кремлевская медицина. Клин. вестн. 2003; 2: 23-8.
- Шляхто Е.В., Беркович О.А., Моисеева О.М. Клеточные и молекулярно - генетические аспекты эндотелиальной дисфункции. Вестн. РАМН. 2004; 10: 50-2.
- Ross R, Glomset J. The pathogenesis of atherosclerosis: part 1. N Engl J Med 1976; 295: 369-77, 420-8.
- Федин А.И., Старых Е.П., Парфенов А.С. и др. Корреляции показателя мозгового кровотока и функций сосудистого эндотелия при атеросклерозе церебральных артерий. Вестн. РГМУ. 2012; 4: 27-31.
- Струков А.И., Серов В.В., Саркисов Д.С. Общая патология человека. Руководство для врачей. В 2 т. Т. 2., изд., перераб. и доп. М.: Медицина, 1990.
