The influence of fixed-dose combination of amlodipine and bisoprolol on vascular elasticity in patients with arterial hypertension

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Abstract

The aim of the study is to evaluate antihypertensive efficacy and effects on the vascular elasticity and metabolic indicators in case of application of two fixed-dose combinations of bisoprolol and amlodipine and enalapril and hydrochlorothiazide in patients with arterial hypertension. Materials and methods. 60 patients suffering from arterial hypertension were included in reference-controlled, randomized blind study among parallel group of drugs: bisoprolol (5 mg) and amlodipine (5 mg), enalapril (10 mg) and hydrochlorothiazide (12.5 mg); all 60 patients were examined initially and after 12 weeks of the treatment for central and peripheral arterial elasticity. Results. There was no significant difference in the antihypertensive efficacy between the drugs. The combination of bisoprolol and amlodipine showed significant positive effect on the indices of angioprotection and lipid and carbohydrate metabolism. The degree of positive effect was highest in patients with baseline heart rate over 75 beats per minute.

About the authors

S. V Nedogoda

Volgograd State Medical University of the Ministry of Health of the Russian Federation

д-р мед. наук, проф., проректор по лечебной работе, зав. каф. терапии и эндокринологии ФУВ ГБОУ ВПО ВолгГМУ 400131, Russian Federation, Volgograd, pl. Pavshikh bortsov, d. 1

A. S Salasiuk

Volgograd State Medical University of the Ministry of Health of the Russian Federation

Email: solarheart7@gmail.com
аспирант, ассистент каф. терапии и эндокринологии ФУВ ГБОУ ВПО ВолгГМУ 400131, Russian Federation, Volgograd, pl. Pavshikh bortsov, d. 1

V. V Tsoma

Volgograd State Medical University of the Ministry of Health of the Russian Federation

канд. мед. наук, ассистент каф. терапии и эндокринологии ФУВ ГБОУ ВПО ВолгГМУ 400131, Russian Federation, Volgograd, pl. Pavshikh bortsov, d. 1

E. V Chumachek

Volgograd State Medical University of the Ministry of Health of the Russian Federation

Email: elena-chumachek@yandex.ru
аспирант, ассистент каф. терапии и эндокринологии ФУВ ГБОУ ВПО ВолгГМУ 400131, Russian Federation, Volgograd, pl. Pavshikh bortsov, d. 1

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