Model of the Destruction of Bioresorbable Polymers in Aqueous Media
- Авторы: Borovikov P.I.1, Antonov E.N.2, Dunaev A.G.2, Krotova L.I.2, Sviridov A.P.2, Fatkhudinov T.K.1, Popov V.K.2
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Учреждения:
- Kulakov Research Center for Obstetrics, Gynecology, and Perinatology
- Federal Scientific Research Center Crystallography and Photonics
- Выпуск: Том 9, № 4 (2018)
- Страницы: 649-654
- Раздел: Article
- URL: https://journals.rcsi.science/2075-1133/article/view/207534
- DOI: https://doi.org/10.1134/S2075113318040056
- ID: 207534
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Аннотация
The destruction of porous matrix polylactoglycolide (PLG) structures with different ratios of lactic and glycolic acids is experimentally studied in phosphate buffer saline. A mathematical model of this destruction that takes into account both the heterogeneous and autocatalytic hydrolysis of PLG as well as diffusion of their oligomers in the buffer solution and polymer free volume is developed. Gel-penetrating chromatography is used to analyze changes in the weight-average molecular weight of specimens studied and to determine the kinetic parameters of this process.
Об авторах
P. Borovikov
Kulakov Research Center for Obstetrics, Gynecology, and Perinatology
Email: sviridoa@gmail.com
Россия, Moscow
E. Antonov
Federal Scientific Research Center Crystallography and Photonics
Email: sviridoa@gmail.com
Россия, Moscow
A. Dunaev
Federal Scientific Research Center Crystallography and Photonics
Email: sviridoa@gmail.com
Россия, Moscow
L. Krotova
Federal Scientific Research Center Crystallography and Photonics
Email: sviridoa@gmail.com
Россия, Moscow
A. Sviridov
Federal Scientific Research Center Crystallography and Photonics
Автор, ответственный за переписку.
Email: sviridoa@gmail.com
Россия, Moscow
T. Fatkhudinov
Kulakov Research Center for Obstetrics, Gynecology, and Perinatology
Email: sviridoa@gmail.com
Россия, Moscow
V. Popov
Federal Scientific Research Center Crystallography and Photonics
Email: sviridoa@gmail.com
Россия, Moscow
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