Место ингибиторов ГМГ-КоА-редуктазы в первичной профилактике сердечно-сосудистых заболеваний: соотношение пользы и риска

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Аннотация

Систематический обзор посвящен анализу места статинов в первичной профилактике сердечно-сосудистых заболеваний (ССЗ). Проанализированы современные международные рекомендации и доказательная база, демонстрирующая эффективность терапии в снижении риска серьезных нежелательных сердечно-сосудистых событий (MACE). Особое внимание уделено дискуссионным вопросам, включая назначение статинов пациентам с промежуточным риском и лицам старше 75 лет, где соотношение пользы и рисков требует строго индивидуального подхода. Подчеркивается благоприятный профиль безопасности статинов, при этом многие субъективные побочные эффекты ассоциированы с ноцебо-феноменом, в то время как наиболее значимыми рисками являются дозозависимое повышение частоты развития сахарного диабета 2 типа и гепатотоксичность. Определение оптимальных критериев терапии, особенно в гериатрической практике, ожидается от результатов текущих масштабных исследований STAREE и PREVENTABLE.

Об авторах

Надежда Владимировна Изможерова

Уральский государственный медицинский университет

Автор, ответственный за переписку.
Email: nadezhda_izm@mail.ru
ORCID iD: 0000-0001-7826-9657

д.м.н., профессор

Россия, Екатеринбург

В. А. Косташ

Уральский государственный медицинский университет

Email: nadezhda_izm@mail.ru
ORCID iD: 0009-0004-8918-4279
Россия, Екатеринбург

М. А. Шамбатов

Уральский государственный медицинский университет

Email: nadezhda_izm@mail.ru
ORCID iD: 0000-0001-7312-415X
Россия, Екатеринбург

А. А. Попов

Уральский государственный медицинский университет

Email: nadezhda_izm@mail.ru
ORCID iD: 0000-0001-6216-2468
Россия, Екатеринбург

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