PharmatecaPharmatecaФарматека2073-40342414-9128Bionika Media38089710.18565/pharmateca.2025.10.45-52Clinical experienceКлинический опытResearch ArticleExperience with the use of a preparation containing polyhexanide and betaine in the treatment of secondary infected dermatosesОпыт использования препарата, содержащего полигексанид и бетаин, в лечении вторично инфицированных дерматозовhttps://orcid.org/0000-0002-5044-5265KruglovaLarisa S.КругловаЛариса Сергеевна
Russian Federation

Dr. Sci. (Med.), Professor, Head of the Department of Dermatovenereology and Cosmetology, Rector

д.м.н., профессор, зав. кафедрой дерматовенерологии и косметологии, ректор

kruglovals@mail.ruhttps://orcid.org/0000-0003-3437-5233GryazevaNatalya V.ГрязеваНаталья Владимировна
Russian Federation

Dr. Sci. (Med.), Professor, Department of Dermatovenereology and Cosmetology

д.м.н., профессор кафедры дерматовенерологии и косметологии

tynrik@yandex.ruhttps://orcid.org/0000-0002-4672-697XTamrazovaAnait V.ТамразоваАнаит Вардановна
Russian Federation

Cand. Sci. (Med.), Associate Professor, Department of Dermatovenereology and Cosmetology

к.м.н., доцент кафедры дерматовенерологии и косметологии

anaittamrazova@gmail.comCentral State Medical Academy of the Administrative Directorate of the President of the Russian FederationЦентральная государственная медицинская академия Управления делами Президента РФ311220253210455203022026Copyright ©; 2025, Bionika MediaCopyright ©; 2025, ООО «Бионика Медиа»2025Bionika MediaООО «Бионика Медиа»https://journals.rcsi.science/2073-4034/article/view/380897

This article examines the problem of secondary infection in atopic dermatitis (AD), caused by impaired skin barrier function and dysbiosis, with a predominance of Staphylococcus aureus. The role of bacterial, fungal, and viral infections in aggravating the disease is emphasized. Three clinical cases demonstrate the effectiveness of a gel containing polyhexanide and betaine. Application of the gel ensured gentle cleansing of crusts and biofilm, exerted an antimicrobial effect, and created optimal conditions for regeneration, significantly increasing the effectiveness of subsequent anti-inflammatory therapy and achieving rapid relief of infection symptoms.

В статье рассматривается проблема вторичного инфицирования при атопическом дерматите (АД), обусловленного нарушением барьерной функции кожи и дисбиозом, с доминированием Staphylococcus aureus. Подчеркивается роль бактериальных, грибковых и вирусных инфекций в усугублении течения заболевания. На примере трех клинических случаев продемонстрирована эффективность геля, содержащего полигексанид и бетаин. Применение геля обеспечивало бережное очищение от корок и биопленки, оказывало антимикробный эффект и создавало оптимальные условия для регенерации, что позволяло значительно повысить эффективность последующей противовоспалительной терапии и добиться быстрого купирования симптомов инфекции.

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