PharmatecaPharmatecaФарматека2073-40342414-9128Bionika Media38089510.18565/pharmateca.2025.10.33-38Clinical experienceКлинический опытResearch ArticleAn epigenetic approach to correcting involutional skin changesЭпигенетический подход к коррекции инволютивных изменений кожиhttps://orcid.org/0000-0002-5044-5265KruglovaL. S.КругловаЛ. С.
Russian Federation

Dr. Sci. (Med.), Professor, Honored Scientist of the Russian Federation, Rector, Head of the Department of Dermatovenereology and Cosmetology

д.м.н., профессор, заслуженный деятель науки Российской Федерации, ректор, зав. кафедрой дерматовенерологии и косметологии

kruglovals@mail.ruhttps://orcid.org/0000-0001-6888-4760PolonskayaA. S.ПолонскаяА. С.
Russian Federation

Cand. Sci. (Med.), Associate Professor, Department of Dermatovenereology and Cosmetology

к.м.н., доцент кафедры дерматовенерологии и косметологии

dr.polonskaia@gmail.comCentral State Medical Academy of the Administrative Directorate of the President of the Russian FederationЦентральная государственная медицинская академия Управления делами Президента РФ311220253210333803022026Copyright ©; 2025, Bionika MediaCopyright ©; 2025, ООО «Бионика Медиа»2025Bionika MediaООО «Бионика Медиа»https://journals.rcsi.science/2073-4034/article/view/380895

The study of aging mechanisms has remained an important area of scientific research for many years. Currently, particular attention is being paid to epigenetic mechanisms of aging. Current knowledge of the epigenetic aspects of age-related skin changes opens up extensive opportunities for the development of therapeutic tools that target the cellular and molecular patterns of skin aging. Epicellin, a flavonoid from Ampelopsis grossedentata, exhibits antioxidant, anti-inflammatory, antibacterial, and antitumor activity. It reactivates youth genes and significantly eliminates signs of skin aging caused by epigenetic changes by inhibiting DNA methyltransferase 1, an enzyme that plays a key role in age-associated pathological DNA methylation.

Изучение механизмов старения на протяжении многих лет остается важным направлением научных исследований. В настоящее время особое внимание уделяется эпигенетическим механизмам старения. Актуальные знания эпигенетических аспектов возрастных изменений кожи открывают широкие возможности для разработки терапевтических инструментов, воздействующих на клеточные и молекулярные паттерны старения кожи. Эпицеллин, являющийся флавоноидом Ampelopsis grossedentata, обладает антиоксидантной, противовоспалительной, антибактериальной и противоопухолевой активностью, реактивирует гены молодости и заметно устраняет признаки старения кожи, вызванные эпигенетическими изменениями за счет ингибирования фермента ДНК-метилтрансферазы 1, играющего важную роль в возраст-ассоциированном патологическом метилировании ДНК.

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