The influence of the surface structure of polyaniline films on the adsorption of influenza A viruses and antibodies to them

Аннотация

Adsorption of influenza A viruses and their antibodies on golden surfaces, thin films of polyaniline and polyaniline complex with polysulfonic acids, has been studied. The composition of interpolymer complexes was found to influence both the surface relief of synthesized films and the adsorption efficiency. Moreover, it has been shown that the adsorption of bio-objects increased with a growth of surface roughness of the polymer coatings. It has been suggested that this effect was caused by an tight contact between the studied bioobjects and the surface relief elements of close size. In addition, the surface protuberances can act as active centers of adsorption due to their larger accessibility. The results testify to the potential of application of films composed of interpolymer polyaniline complexes with a developed surface relief as a basis to prepare biosensors that are sensitive to viruses and antibodies.