Supercritical Fluid Treatment of Three-Dimensional Hydrogel Matrices Obtained from Allylchitosan by Laser Stereolithography


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The effect of the treatment of hydrogel matrices based on allyl-substituted chitosans and formed by laser stereolithography in supercritical carbon dioxide (SC-CO2) on their surface polarity and mechanical characteristics was studied. Treatment in a flow mode increased the mechanical stability of the materials due to the effective extraction of the low-molecular components and oligomers. The surface polarity of the matrix decreased, improving its biocompatibility. The hydrogel matrices treated in SC-CO2 have no cytotoxic activity, due to which they can be used in tissue engineering.

作者简介

A. Lazhko

Institute of Photon Technologies, Crystallography and Photonics Research Center; Faculty of Chemistry

编辑信件的主要联系方式.
Email: alexeylazhko@mail.ru
俄罗斯联邦, Troitsk (Moscow); Moscow, 119991

K. Bardakova

Institute of Photon Technologies, Crystallography and Photonics Research Center; Institute of Regenerative Medicine

Email: alexeylazhko@mail.ru
俄罗斯联邦, Troitsk (Moscow); Moscow, 119991

B. Shavkuta

Institute of Photon Technologies, Crystallography and Photonics Research Center

Email: alexeylazhko@mail.ru
俄罗斯联邦, Troitsk (Moscow)

S. Churbanov

Institute of Photon Technologies, Crystallography and Photonics Research Center

Email: alexeylazhko@mail.ru
俄罗斯联邦, Troitsk (Moscow)

M. Markov

Institute of Problems of Laser and Information Technologies

Email: alexeylazhko@mail.ru
俄罗斯联邦, Shatura, Moscow oblast, 140700

T. Akopova

Enikolopov Institute of Synthetic Polymer Materials

Email: alexeylazhko@mail.ru
俄罗斯联邦, Moscow, 117393

O. Parenago

Faculty of Chemistry; Kurnakov Institute of General and Inorganic Chemistry

Email: alexeylazhko@mail.ru
俄罗斯联邦, Moscow, 119991; Moscow, 119991

A. Grigoryev

Academician Shumakov Federal Research Center of Transplantation and Artificial Organs

Email: alexeylazhko@mail.ru
俄罗斯联邦, Moscow, 123182

P. Timashev

Institute of Photon Technologies, Crystallography and Photonics Research Center; Institute of Regenerative Medicine

Email: alexeylazhko@mail.ru
俄罗斯联邦, Troitsk (Moscow); Moscow, 119991

V. Lunin

Faculty of Chemistry; Kurnakov Institute of General and Inorganic Chemistry

Email: alexeylazhko@mail.ru
俄罗斯联邦, Moscow, 119991; Moscow, 119991

V. Bagratashvili

Institute of Photon Technologies, Crystallography and Photonics Research Center; Faculty of Chemistry

Email: alexeylazhko@mail.ru
俄罗斯联邦, Troitsk (Moscow); Moscow, 119991

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