Sterilization of a porous ultrahigh-molecular-weight polyethylene in supercritical Freons

D. Yu. Zalepugin; A. V. Maksimkin; M. V. Kiselevsky; N. A. Tilkunova; N. Yu. Anisimova; I. V. Chernysheva; F. S. Senatov; M. I. Vlasov

doi:10.1134/S1990793116080170

Sterilization of a porous ultrahigh-molecular-weight polyethylene in supercritical Freons

作者: Zalepugin D.Y.¹, Maksimkin A.V.², Kiselevsky M.V.²^,3, Tilkunova N.A.¹, Anisimova N.Y.²^,3, Chernysheva I.V.¹, Senatov F.S.², Vlasov M.I.¹
隶属关系:
1. Federal State Unitary Enterprise “State Plant of Medicinal Drugs”
2. National University of Science and Technology “MISIS”
3. Blokhin Russian Cancer Research Center
期: 卷 10, 编号 8 (2016)
页面: 1264-1268
栏目: Article
URL: https://journals.rcsi.science/1990-7931/article/view/198830
DOI: https://doi.org/10.1134/S1990793116080170
ID: 198830

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The possibility of sterilization of porous ultrahigh-molecular-weight polyethylene in subcritical Freons R22 and R410a in the absence of modifiers is for the first time demonstrated. The maximum sterilization effect is achieved when sterilization with Freon R410a is performed in static conditions for 30 min at 50°С and 250 bar or with Freon R22 for 60 min at 70°С and cyclically varied pressure within 100–290 bar (press–depress mode).