Product fermented by Lactobacilli induces changes in intracellular calcium dynamics in rat brain neurons


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In this work we investigated the effect of concentrated metabolic products of lactobacilli (PP) on the dynamics of intracellular calcium concentration ([Ca2+]i) in rat brain neurons. [Ca2+]i was recorded using a fluorescent probe Fura-2 and a ratiometric Ca2+ imaging. It was found that PP increased [Ca2+]i, stimulating the intracellular signaling mechanisms. In these processes the activation of ryanodine receptors and protein kinase C are involved at least partially. Continuous application of PP stimulated a sustained release of Ca2+ from the endoplasmic reticulum and subsequent entry of Ca2+ into the cell. Given that PP is able to stimulate circulation and neurogenesis and is involved in calcium homeostasis in nerve cells in the brain, PP can be regarded as a product for the improvement of psychological parameters and cognitive functions of the brain.

Sobre autores

C. Sobol

Sechenov Institute of Evolutionary Physiology and Biochemistry

Autor responsável pela correspondência
Email: peep9@yandex.ru
Rússia, pr. Thoreza 44, St. Petersburg, 194223

G. Belostotskaya

Sechenov Institute of Evolutionary Physiology and Biochemistry

Email: peep9@yandex.ru
Rússia, pr. Thoreza 44, St. Petersburg, 194223

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