Participation of Septin Cytoskeletal Proteins in the Nervous System Functioning
- Авторы: Bukharaeva E.1,2, Khuzakhmetova V.1,2
-
Учреждения:
- Kazan Institute of Biochemistry and Biophysics
- Kazan (Volga region) Federal University
- Выпуск: Том 12, № 1 (2018)
- Страницы: 1-9
- Раздел: Reviews
- URL: https://journals.rcsi.science/1990-7478/article/view/213281
- DOI: https://doi.org/10.1134/S1990747818010026
- ID: 213281
Цитировать
Аннотация
Septins, the cytoskeletal proteins discovered in the 1970s in budding yeast cells, are currently detected in most postmitotic cells of animals and humans. In the last decade, significant progress has been made in understanding the biochemical properties of septins and their biological functions. An increasing number of studies show that these proteins play an important role in the development and physiology of specific tissues and organs. The review surveys classification, major functions and localization of septins in the nervous system of mammals and humans. Models describing the mechanisms of the septin involvement in the neurotransmitter secretion from nerve endings and the role of septins in the pathogenesis of various neurodegenerative diseases are discussed.
Ключевые слова
Об авторах
E. Bukharaeva
Kazan Institute of Biochemistry and Biophysics; Kazan (Volga region) Federal University
Автор, ответственный за переписку.
Email: elbukhara@gmail.com
Россия, Kazan, 420111; Kazan, 420008
V. Khuzakhmetova
Kazan Institute of Biochemistry and Biophysics; Kazan (Volga region) Federal University
Email: elbukhara@gmail.com
Россия, Kazan, 420111; Kazan, 420008