Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease
- Autores: Dolgacheva L.1, Fedotova E.1, Abramov A.2, Berezhnov A.1
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Afiliações:
- Istitute of Cell Biophysics of Russian Academy of Sciences
- Department of Molecular Neuroscience
- Edição: Volume 12, Nº 1 (2018)
- Páginas: 10-19
- Seção: Reviews
- URL: https://journals.rcsi.science/1990-7478/article/view/213282
- DOI: https://doi.org/10.1134/S1990747818010038
- ID: 213282
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Resumo
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. The development of pathology is associated with the loss of dopaminergic neurons, mainly in substantia nigra pars compacta. Dopamine deficiency causes a whole range of severe motor symptoms, including bradykinesia, postural instability, muscle rigidity, and tremor. Studies have shown the primary role of the alpha-synuclein protein in this neurodegenerative disease. A large amount of data indicates different mechanisms of the toxic effect of alpha-synuclein. The process of neurodegeneration in PD is the result of significant disturbances in mitochondrial functions and/or genetic mutations. The number of mutated genes in hereditary and sporadic forms of Parkinson’s disease includes genes encoding PINK1 and Parkin, which are the main participants in the mitochondrial “quality control” system. The earliest biochemical hallmarks of the disease are disturbances of the mitochondrial interaction with endoplasmic reticulum, mitochondrial dynamics, Ca2+ homeostasis, and an increase in the level of mitochondrial reactive oxygen species. All these factors exert damaging effects on dopaminergic neurons.
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Sobre autores
L. Dolgacheva
Istitute of Cell Biophysics of Russian Academy of Sciences
Email: g_56@rambler.ru
Rússia, Pushchino, Moscow oblast, 142290
E. Fedotova
Istitute of Cell Biophysics of Russian Academy of Sciences
Email: g_56@rambler.ru
Rússia, Pushchino, Moscow oblast, 142290
A. Abramov
Department of Molecular Neuroscience
Email: g_56@rambler.ru
Reino Unido da Grã-Bretanha e Irlanda do Norte, Queen Square, London, WC1N 3BG
A. Berezhnov
Istitute of Cell Biophysics of Russian Academy of Sciences
Autor responsável pela correspondência
Email: g_56@rambler.ru
Rússia, Pushchino, Moscow oblast, 142290