Endothelial Cells of Atherosclerotic Coronary Arteries in vivo Obtained during Angioplasty (Intravascular Biopsy)
- Авторы: Tarasov A.1, Kravtsov V.2, Khirmanov V.1, Ellinidi V.1, Wassilew K.3
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Учреждения:
- Nikiforov Russian Center of Emergency and Radiation Medicine
- Military Medical Academy by S. M. Kirov
- Rigshospitalet
- Выпуск: Том 12, № 4 (2018)
- Страницы: 289-295
- Раздел: Article
- URL: https://journals.rcsi.science/1990-519X/article/view/212704
- DOI: https://doi.org/10.1134/S1990519X18040107
- ID: 212704
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Аннотация
The relevance of our study is due to the unresolved problem of atherosclerosis, a disease that causes a greatest many disabilities and deaths. A definite value in its initiation, progression, and destabilization is assigned to endothelial cells, which are prone to pathological effects of various factors. In patients with atherosclerosis, it is impossible to obtain endothelial cells in vivo and in situ and, accordingly, to characterize their cytological features. Endothelial biopsy in this work was performed by coronary angioplasty in 64 patients with various clinical forms of coronary heart disease. A balloon catheter was used as a probe for biopsy. Preparations of endothelial biopsy were prepared using the principles of liquid-based cytology. Anucleated, polygonal cells with nuclei and their clusters, as well as apoptotic bodies with the immunophenotype CD31+, CD34+, CD105+/–, PanCk+/–, CD45–, and CD68–, have been obtained. It is confirmed that they belong to the endothelium, which shows that further cytological studies can be carried out with the purpose of evaluating the etiology and pathogenesis of atherosclerotic processes.
Об авторах
A. Tarasov
Nikiforov Russian Center of Emergency and Radiation Medicine
Автор, ответственный за переписку.
Email: tarasovmed@gmail.com
Россия, St. Petersburg, 197345
V. Kravtsov
Military Medical Academy by S. M. Kirov
Email: tarasovmed@gmail.com
Россия, St. Petersburg, 194044
V. Khirmanov
Nikiforov Russian Center of Emergency and Radiation Medicine
Email: tarasovmed@gmail.com
Россия, St. Petersburg, 197345
V. Ellinidi
Nikiforov Russian Center of Emergency and Radiation Medicine
Email: tarasovmed@gmail.com
Россия, St. Petersburg, 197345
K. Wassilew
Rigshospitalet
Email: tarasovmed@gmail.com
Дания, Copenhagen