Optimization of Mechanical Properties and Bioactivity of Composite Matrices Based on Chitosan and Chitin Nanofibril for Tissue Engineering


Citar

Texto integral

Acesso aberto Acesso aberto
Acesso é fechado Acesso está concedido
Acesso é fechado Somente assinantes

Resumo

This paper discusses the mechanical properties of chitosan-based film matrices, as well as optimization of these properties by adding chitin nanofibrils. It has been shown that the filler addition stabilizes the mechanical properties of the composite material. By changing the concentration of chitin nanofibrils, it is possible to obtain matrices with different bioactive properties for cultured human dermal fibroblasts. The optimal balance of mechanical properties and bioactivity in relation to the culture of human dermal fibroblasts is possessed by film matrices based on chitosan nanocomposite with the addition of 5% chitin nanofibrils. Film matrices based on chitosan nanocomposite with the addition of 5% chitin nanofibrils provide the optimal balance of mechanical properties and bioactivity for cultured human dermal fibroblasts.

Sobre autores

N. Smirnova

Institute of Macromolecular Compounds, Russian Academy of Sciences; Peter the Great St. Petersburg Polytechnic University

Autor responsável pela correspondência
Email: nvsmirnoff@yandex.ru
Rússia, St. Petersburg, 199004; St. Petersburg, 195251

K. Kolbe

Peter the Great St. Petersburg Polytechnic University

Email: nvsmirnoff@yandex.ru
Rússia, St. Petersburg, 195251

E. Dresvyanina

Institute of Macromolecular Compounds, Russian Academy of Sciences

Email: nvsmirnoff@yandex.ru
Rússia, St. Petersburg, 199004

I. Dobrovolskaya

Institute of Macromolecular Compounds, Russian Academy of Sciences; Peter the Great St. Petersburg Polytechnic University

Email: nvsmirnoff@yandex.ru
Rússia, St. Petersburg, 199004; St. Petersburg, 195251

V. Yudin

Institute of Macromolecular Compounds, Russian Academy of Sciences; Peter the Great St. Petersburg Polytechnic University

Email: nvsmirnoff@yandex.ru
Rússia, St. Petersburg, 199004; St. Petersburg, 195251

Arquivos suplementares

Arquivos suplementares
Ação
1. JATS XML

Declaração de direitos autorais © Pleiades Publishing, Ltd., 2019