The Influence of an Electret-Generated Electric Field Based on a Tantalum Oxide Anode on Differentiation Properties of Bone Marrow Stromal Cells from Patients with Osteoarthritis
- Autores: Aleksandrova S.1, Aleksandrova O.1, Khomutov V.2, Morgunov M.2, Blinova M.1
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Afiliações:
- Institute of Cytology, Russian Academy of Sciences, Russian Academy of Sciences
- LLC Medel
- Edição: Volume 13, Nº 2 (2019)
- Páginas: 144-151
- Seção: Article
- URL: https://journals.rcsi.science/1990-519X/article/view/212912
- DOI: https://doi.org/10.1134/S1990519X19020020
- ID: 212912
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Resumo
The ability of the bone marrow multipotent mesenchymal stromal cells (MMSCs) of a patient with osteoarthritis to differentiate into the osteogenic and chondrogenic lineages under the influence of an electret-generated electric field created on the surface of anodic tantalum oxide was investigated. It has been shown that the synthesis of protein-differentiation markers in MMSCs is intensified in the presence of samples with anodic oxide in the electret state. The effect of electrets with uniform charge distribution over the surface was compared with linear charge distribution, MMSCs osteogenic differentiation was accompanied with enhanced expression of osteocalcin and type I collagen. These features were exhibited much stronger in cells exposed to electret specimens with a charge distribution on the surface close to linear.
Sobre autores
S. Aleksandrova
Institute of Cytology, Russian Academy of Sciences, Russian Academy of Sciences
Autor responsável pela correspondência
Email: alekssvet2205@gmail.com
Rússia, St. Petersburg, 194064
O. Aleksandrova
Institute of Cytology, Russian Academy of Sciences, Russian Academy of Sciences
Email: alekssvet2205@gmail.com
Rússia, St. Petersburg, 194064
V. Khomutov
LLC Medel
Email: alekssvet2205@gmail.com
Rússia, St. Petersburg, 194044
M. Morgunov
LLC Medel
Email: alekssvet2205@gmail.com
Rússia, St. Petersburg, 194044
M. Blinova
Institute of Cytology, Russian Academy of Sciences, Russian Academy of Sciences
Email: alekssvet2205@gmail.com
Rússia, St. Petersburg, 194064