The efficacy of mesenchymal stem cells for the improvement of cerebral microcirculation in spontaneously hypertensive rats

Abstract

Elaboration of new correction methods for microcirculatory disorders in the brain caused by persistent high blood pressure is important for both medicine and biology. We studied the influence of intracerebral transplantation of human mesenchymal stem cells (hMSCs) on the cerebral microcirculation in young (4 month) and mature (12 month) spontaneously hypertensive rats (SHRs). It was shown that hMSC transplantation increased the density of the microvascular network of young SHRs to 1.6 and 1.9 times the density of the arteriolar area of the microvascular network of the pia. The density of microvascular network of mature SHRs increased by 1.4–1.5 times after hMSC transplantation. The perfusion and tissue saturation of sensorimotor cortex of young SHRs restored to the level of young normotensive rats. In mature SHRs, the perfusion and tissue saturation of sensorimotor cortex did not increase. In conclusion, the intracerebral transplantation of hMSC almost completely restored microcirculation in the sensorimotor cortex of the brain of young SHRs and slightly improved microcirculation in mature SHRs.