Neuroautoimmune Processes in Vibration Disease

Abstract

To study the relationship between neurochemical changes in specialized tissue structures and the state of the conducting pathways of the central and peripheral nervous system, we analyzed the levels of neuronal antibodies (ABs), somatosensory evoked potentials, and electroneuromyography in patients with vibration disease (VD) induced by local vibration. We found correlations between the concentrations of ABs against NF-200, MBP, S-100, GFAP, B2GP, Ser-P, DNA, voltage-dependent Ca channel, Glu-P and changes in the central conductive structures; as well as between ABs against MBP, GFAP, DNA, Ser-P, S-100 GABA-P, DA-P, Glu-P, AX-P and the rate of impulses along axons of various structures of the nervous system. The revealed interrelationships confirm the functional integration of the nervous and immune systems and the important role of autoimmune reactions in the development and course of VD. Possible mechanisms of neurotransmitter metabolism disorders and demyelination are discussed. These results may serve as a basis for the development of new informative laboratory indicators and differential diagnostics of subjects working under the influence of local vibration.