Malignant neoplasm of the bronchi and lung: Russian clinical guidelines

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Lung cancer has the highest morbidity rate among all malignant tumors in men and the highest mortality rate in men and women in Russia. In total, 49 145 new cases of lung cancer were registered (diagnosed) in Russia in 2019. The majority of cases are related to exogenic carcinogens and mainly tobacco smoke. For several decades surgical resection with preoperative cytotoxic therapy was an optimal approach for maximal cure rate. This year recommendations were updated with new strategies including adjuvant anti-PD-L1 atezolizumab following completion of chemotherapy in PD-L1 positive patients and osimertinib for EGFR mutated cases. For this moment available data suggest the increase in disease free survival. Strategic approach to treatment for inoperable patients varies according to the status of driver mutations. New approach includes pretreatment option of testing for a wide spectrum of alterations with NGS based panels. Significant changes were incorporated into treatment of ALK mutated NSCLC with two new options of brigatinib for TKI naive patients and lorlatinib for those who progress on second generation drugs. Treatment strategy for patients without activating mutations is based on PD-L1 status. Tsis year recommendations included atezolizumab as a new monotherapy option for patients with high depression of PD-L1. Also treatment options for pembrolizumab, nivolumab and atezolizimab were widened with prolonged treatment schedules.

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Konstantin Laktionov

Blokhin National Medical Research Center of Oncology

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俄罗斯联邦, Moscow

Elena Artamonova

Blokhin National Medical Research Center of Oncology

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俄罗斯联邦, Moscow

Tatiana Borisova

Blokhin National Medical Research Center of Oncology

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Valerii Breder

Blokhin National Medical Research Center of Oncology

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Iurii Bychkov

Russian Scientific Center of Roentgenoradiology

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Liubov Vladimirova

Blokhin National Medical Research Center of Oncology

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Nikita Volkov

Saint Petersburg Clinical Research and Practical Center for Specialized Types of Medical Care (Oncologic)

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Stepan Ergnian

Petrov National Medical Research Center of Oncology

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Albina Zhabina

Saint Petersburg Clinical Research and Practical Center for Specialized Types of Medical Care (Oncologic)

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Pavel Kononets

Blokhin National Medical Research Center of Oncology

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Aleksandr Kuz’minov

Blokhin National Medical Research Center of Oncology

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Evgenii Levchenko

Petrov National Medical Research Center of Oncology

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Olga Malikhova

Blokhin National Medical Research Center of Oncology

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Dimitr Marinov

Blokhin National Medical Research Center of Oncology

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Sergei Miller

Tomsk National Research Medical Center of the Russian Academy of Sciences

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Fedor Moiseenko

Saint Petersburg Clinical Research and Practical Center for Specialized Types of Medical Care (Oncologic)

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Valeriia Mochal’nikova

Blokhin National Medical Research Center of Oncology

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Sergei Novikov

Petrov National Medical Research Center of Oncology

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Oleg Pikin

Herzen Moscow Scientifuc Research Institute of Oncology – branch of the National Medical Research Center for Radiology

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Elena Reutova

Blokhin National Medical Research Center of Oncology

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Evgenii Rodionov

Tomsk National Research Medical Center of the Russian Academy of Sciences

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Dina Sakaeva

Republican Clinical Oncology Center of Ministry of Healthcare of the Republic of Bashkortostan

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Anna Semenova

Petrov National Medical Research Center of Oncology

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Burdenko Main Military Clinical Hospital

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Russian Scientific Center of Roentgenoradiology

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Tomsk National Research Medical Center of the Russian Academy of Sciences

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Rostov Research Institute of Oncology

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Igor Tiurin

Russian Medical Academy of Continuous Professional Education

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Vladimir Chkhikvadze

Russian Scientific Center of Roentgenoradiology

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Konstantin Kolbanov

Herzen Moscow Scientifuc Research Institute of Oncology – branch of the National Medical Research Center for Radiology

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Andrei Chernichenko

Herzen Moscow Scientifuc Research Institute of Oncology – branch of the National Medical Research Center for Radiology

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Aleksandr Fedenko

Herzen Moscow Scientifuc Research Institute of Oncology – branch of the National Medical Research Center for Radiology

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Elena Filonenko

Herzen Moscow Scientifuc Research Institute of Oncology – branch of the National Medical Research Center for Radiology

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Aleksei Nevol’skikh

Tsyb Medical Radiological Scientific Center – branch of the National Medical Research Center for Radiology

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Sergei Ivanov

Tsyb Medical Radiological Scientific Center – branch of the National Medical Research Center for Radiology

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Tigran Gevorkian

Blokhin National Medical Research Center of Oncology

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Blokhin National Medical Research Center of Oncology

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Ilmira Gil’mutdinova

National Medical Research Center of Rehabilitation and Balneology

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Irina Gridneva

Burdenko Voronezh State Medical University

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Mikhail Eremushkin

National Medical Research Center of Rehabilitation and Balneology

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Margarita Zernova

Petrov National Medical Research Center of Oncology

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Boris Kasparov

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Denis Kovlen

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Kristina Kondrat’eva

Petrov National Medical Research Center of Oncology

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Tatiana Konchugova

National Medical Research Center of Rehabilitation and Balneology

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Svetlana Korotkova

Burdenko Voronezh State Medical University

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Anton Krutov

Petrov National Medical Research Center of Oncology

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oncologist

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Olga Obukhova

Blokhin National Medical Research Center of Oncology

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Petrov National Medical Research Center of Oncology; Mechnikov North-Western State Medical University

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Blokhin National Medical Research Center of Oncology

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