PARP inhibitors in female reproductive system cancers


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PARP-1 and PARP-2 enzymes are one of six known DNA damage repair systems - nitrogenous base excision repair. PARP inhibitor disrupts excision repair and under the conditions of the absence of another pathway of DNA damage repair (homologous recombination) can cause apoptosis in tumor cells. One of the most frequent causes of defects in homologous recombination is the loss of BRCA1 or BRCA2 function by means of inactivated mutations. It makes PARP-inhibitors the most effective in the treatment of tumors associated with BRCA germline and somatic mutations. This paper discusses the differences of PARP inhibitors (olaparib, niraparib, veliparib, rucaparib and talazoparib), the results of their clinical trials for female reproductive system cancers, toxicity of PARP inhibitors as monotherapy or in combination with cytotoxic drugs, as well as the registration of these products in Russia and in other countries.

作者简介

I Pokataev

N.N.Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation

Email: pokia@mail.ru
канд. мед. наук, ст. науч. сотр. отд-ния клинической фармакологии и химиотерапии ФГБУ «РОНЦ им. Н.Н.Блохина» 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

S Tyulyandin

N.N.Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation

проф., зав. отд-нием клинической фармакологии и химиотерапии ФГБУ «РОНЦ им. Н.Н.Блохина» 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

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