Male breast cancer: review of the literature


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Male breast cancer (MBC) is a rare condition that accounts for 0,1% of all male cancers. Our current evidence base for treatment is derived from female breast cancer (FBC) patients. Risk factors for MBC include age, genetic predisposition, race, sex hormone exposure, and environmental factors. Most patients present later and with more advanced disease than comparable FBC patients. Tumors are likely to be estrogen receptor and progesterone receptor positive, with the most common histologic type being invasive ductal carcinoma. Triple assessment remains the criterion standard for diagnosis. Primary MBC is mostly managed initially by simple mastectomy, with the option of breast conserving surgery, which carries an increased risk of recurrence. Sentinel node biopsy is recommended as the initial procedure for staging the axilla. Reconstructive surgery focuses on achieving primary skin closure, and radiotherapy largely follows treatment protocols validated in FBC. We recommend chemotherapy for men with more advanced disease, in particular, those with estrogen receptor negative histology. MBC responds well to endocrine therapy, although it is associated with significant adverse effects. Third-generation aromatase inhibitors are promising but raise concerns due to their failure to prevent estrogen synthesis in the testes. Fulvestrant remains unproven as a therapy, and data on trastuzumab is equivocal with HER2-receptor expression and functionality unclear in MBC. In metastatic disease, drug-based hormonal manipulation remains a first-line therapy, followed by systemic chemotherapy for hormone-refractory disease. Prognosis for MBC has improved over the past 30 years, with survival affected by disease staging, histologic classification, and comorbidity.

作者简介

K Nikolaev

N.N.Petrov Research Institute of Oncology (197758, Leningradskaya Str. 68, Pesochny-2, St.-Petersburg, Russia)

Email: kirill.nikolaev87@gmail.com
врач-онколог хирургического отд-ния опухолей молочной железы

V Semiglazov

N.N.Petrov Research Institute of Oncology (197758, Leningradskaya Str. 68, Pesochny-2, St.-Petersburg, Russia)

д-р мед. наук, проф., чл.-кор. РАМН, рук. отд. опухолей репродуктивной системы, науч. рук. отд-ния опухолей молочной железы

V Semiglazov

I.P.Pavlov Saint-Petersburg State Medical University (197022, L'va Tolstogo str. 6/8, St.-Petersburg, Russia)

д-р мед. наук, зав. каф. онкологии

参考

  1. Семиглазов В.Ф., Семиглазов В.В., Клецель А.Е. Рак молочной железы у мужчин. Неинвазивные и инвазивные опухоли молочной железы. Спб.: Боргес, 2006; с. 288-99.
  2. Семиглазов В.Ф., Семиглазов В.В., Дашян Г.А. и др. Рак молочной железы у мужчин. Фарматека. 2010; 6 (200): 40-5.
  3. Семиглазов В.Ф., Семиглазов В.В., Манихас А.Г. Рак молочной железы. Химиотерапия и таргетная терапия. М.: Медпресс - информ, 2012.
  4. Anderson W.F, Althuis M.D, Brinton L.A et al. Is male breast cancer similar or different than female breast cancer? Breast Cancer Res Treat 2004; 83: 77-86.
  5. Korde L.A, Zujewski J.A, Kamin L et al. Multidisciplinary meeting on male breast cancer: summary and research recommendations. J Clin Oncol 2010; 28: 2114-22.
  6. Giordano S.H, Cohen D.S, Buzdar A.U et al. Breast carcinoma in men: a population - based study. Cancer 2004; 101: 51-7.
  7. Chen V.W, Correa P, Kurman R.J et al. Histological characteristics of breast carcinoma in blacks and whites. Canter Epid Biomarkers Prev 1994; 3: 127-35.
  8. Erlichman C, Murphy К.С, Elhakim T. Male breast cancer: a 13-year review of 89 patients. J Clin Oncol 1984; 2: 903-9.
  9. Johansen Taber K.A, Morisy L.R, Osbahr A.J et al. Male breast cancer: risk factors, diagnosis, and management (review). Oncol Rep 2010; 24: 1115-20.
  10. Palli D, Falchetti M, Masala G et al. Association between the BRCA2 N372H variant and male breast cancer risk: a population - based case - control study in Tuscany, Central Italy. BMC Cancer 2007; 7: 170.
  11. Martin A.M, Weber B.L. Genetic and hormonal risk factors in breast cancer. J Natl Cancer Inst 2000; 92: 1126-35.
  12. Thorlacius S, Tryggvadottir L, Olafsdottir G.H et al. Linkage to BRCA2 region in hereditary male breast cancer. Lancet 1995; 346: 544-5.
  13. Orr N, Lemnrau A, Cooke R et al. Genome - wide association study identifies a common variant in RAD51B associated with male breast cancer risk. Nat Genet 2012; 44: 1182-4.
  14. McClure J.A, Higgins C.C. Bilateral carcinoma of male breast after estrogen therapy. J Am Med Assoc 1951; 146: 7-9.
  15. Symmers W.S. Carcinoma of breast in trans - sexual individuals after surgical and hormonal interference with the primary and secondary sex characteristics. Br Med J 1968; 2: 83-5.
  16. Hultborn R, Hanson C, Köpf I et al. Prevalence of Klinefelter's syndrome in male breast cancer patients. Anticancer Res 1997; 17: 4293-7.
  17. Swerdlow A.J, Schoemaker M.J, Higgins C.D et al. Cancer incidence and mortality in men with Klinefelter syndrome: a cohort study. J Natl Cancer Inst 2005; 97: 1204-10.
  18. Krause W. Male breast cancer - an andrological disease: risk factors and diagnosis. Andrologia 2004; 36: 346-54.
  19. Thomas D.B, Jimenez L.M, McTiernan A et al. Breast cancer in men: risk factors with hormonal implications. Am J Epid 1992; 135: 734-48.
  20. Sorensen H.T, Friis S, Olsen J.H et al. Risk of breast cancer in men with liver cirrhosis. Am J Gastroenterol 1998; 93: 231-3.
  21. Lahmann P.H, Friedenreich C, Schuit A.J et al. Physical activity and breast cancer risk: the European Prospective Investigation into Cancer and Nutrition. Cancer Epid Biomarkers Prev 2007; 16: 36-42.
  22. Ron E, Ikeda T, Preston D.L et al. Male breast cancer incidence among atomic bomb survivors. J Natl Canter Inst 2005; 97: 603-5.
  23. Hansen J. Elevated risk for male breast cancer after occupational exposure to gasoline and vehicular combustion products. Am J Ind Med 2000; 37: 349-52.
  24. Agrawal A, Ayantunde A.A, Rampaul R et al. Male breast cancer: a review of clinical management. Breast Cancer Res Treat 2007; 103: 11-21.
  25. Gu G.L, Wang S.L, Wei X.M et al. Axillary metastasis as the first manifestation of male breast cancer: a case report. Cases J 2008; 1: 285.
  26. Fentiman I.S, Fourquet A, Hortobagyi G.N. Male breast cancer. Lancet 2006; 367: 595-604.
  27. Stewart R.A, Howlett D.C, Hearn F.J. Pictorial review: the imaging features of male breast disease. Clin Radiol 1997; 52: 739-44.
  28. Doyle S, Steel J, Porter G. Imaging male breast cancer. Clin Radiol 2011; 66: 1079-85.
  29. Yang W.T, Whitman G.J, Yuen E.H et al. Sonographic features of primary breast cancer in men. AJR Am J Roentgenol 2001; 176: 413-6.
  30. Ozdemir А, Оznur I.I, Vural G et al. TL-201 scintigraphy, mammography and ultrasonography in the evaluation of palpable and nonpalpable breast lesions: a correlative study. Eur J Radiol 1997; 24: 145-54.
  31. Rosen D.G, Laucirica R, Verstovsek G. Fine needle aspiration of male breast lesions. Acta Cytol 2009; 53: 369-74.
  32. Wauters C.A.P, Kooistra B.W, de Kievit van der Heijden IM et al. Is cytology useful in the diagnostic workup of male breast lesions? A retrospective study over a 16-year period and review of the recent literature. Acta Cytol 2010; 54: 259-64.
  33. Boerner S, Fornage B.D, Singletary E et al. Ultrasound - guided fine - needle aspiration (FNA) of nonpalpable breast lesions: a review of 1885 FNA cases using the National Cancer Institute - supported recommendations on the uniform approach to breast FNA. Cancer 1999; 87: 19-24.
  34. Westenend P.J. Core needle biopsy in male breast lesions. J Clin Pathol 2003; 56: 863-5.
  35. Ottini L, Palli D, Rizzo S et al. Male breast cancer. Crit Rev Oncol Hematol 2010; 73: 141-55.
  36. Ribeiro G.G, Swindell R, Harris M et al. A review of the management of the male breast carcinoma based on an analysis of 420 treated cases. Breast 1996; 5: 141-6.
  37. Bloom K.J, Govil H, Gattuso P et al. Status of HER-2 in male and female breast carcinoma. Am J Surg 2001; 182: 389-92.
  38. Goss P.E, Reid C, Pintilie M et al. Male breast carcinoma: a review of 229 patients who presented to the Princess Margaret Hospital during 40 years: 1955-1996. Cancer 1999; 85: 629-39.
  39. Cutuli B, Dilhuydy J.M, De Lafontan B et al. Ductal carcinoma in situ of the male breast. Analysis of 31 cases. Eur J Cancer 1997; 33: 35-8.
  40. Golshan M, Rusby J, Dominguez F et al. Breast conservation for male breast carcinoma. Breast 2007; 16: 653-6.
  41. Fogh S, Kachnic L.A, Goldberg S.I, Taghian A.G et al. Localized therapy for male breast cancer: functional advantages with comparable outcomes using breast conservation. Clin Breast Cancer 2013; 13 (5): 344-9.
  42. Donegan W.L, Redlich P.N. Breast cancer in men. Surg Clin North Am 1996; 76: 343-63.
  43. Hill A.D, Borgen P.I, Cody H.S. Sentinel node biopsy in male breast cancer. Eur J Surg Oncol 1999; 25: 442-3.
  44. Boughey J.C, Bedrosian I, Meric-Bernstam F et al. Comparative analysis of sentinel lymph node operation in male and female breast cancer patients. J Am Coll Surg 2006; 203: 475-80.
  45. Schlag P.M, Bembenek A. Specification of potential indications and contraindications of sentinel lymph node biopsy in breast cancer. Recent Results Cancer Res 2000; 157: 228-36.
  46. Wong S.L, Chao C, Edwards M.J et al. Accuracy of sentinel lymph node biopsy for patients with T2- and T3-breast cancers. Am Surg 2001; 67: 522-6, disc. 527-8.
  47. Izquierdo M.A, Alonso C, De Andres L et al. Male breast cancer. Report of a series of 50 cases. Acta Oncol 1994; 33: 767-71.
  48. Scott-Connеr C.E, Jochimsen P.R, Menck H.R et al. An analysis of male and female breast cancer treatment and survival among demographically identical pairs of patients. Surgery 1999; 126: 775-80, disc. 780-1.
  49. Bagley C.S, Wesley M.N, Young R.C et al. Adjuvant chemotherapy in males with cancer of the breast. Am J Clin Oncol 1987; 10: 55-60.
  50. Giordano S.H, Perkins G.H, Broglio K et al. Adjuvant systemic therapy for male breast carcinoma. Cancer 2005; 104: 2359-64.
  51. Pemmaraju N, Munsell M.F, Hortobagyi G.N et al. Retrospective review of male breast cancer patients: analysis of tamoxifen - related side - effects. Ann Oncol 2012; 23: 1471-4.
  52. Nabholtz J.M, Buzdar A, Pollak M et al. Anastrozole is superior to tamoxifen as first - line therapy for advanced breast cancer in postmenopausal women: results of a North American multicenter randomized trial. Arimidex Study Group. J Clin Oncol 2000; 18: 3758-67.
  53. Bonneterre J, Thurlimann B, Robertson J.F et al. Anastrozole vs. tamoxifen as first - line therapy for advanced breast cancer in 668 postmenopausal women: results of the Tamoxifen or Arimidex Randomized Group Efficacy and Tolerability Study. J Clin Oncol 2000; 18: 3748-57.
  54. Goldhirsch A, Ingle J.N, Gelber R.D et al. Thresholds for therapies: high - lights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer. Ann Oncol 2009; 20: 1319-29.
  55. Giordano S.H, Valero V, Buzdar A.U et al. Efficacy of anastrozole in male breast cancer. Am J Clin Oncol 2002; 25: 235-7.
  56. Rudlowski C. Male breast cancer. Breast Care (Basel) 2008; 3: 183-9.
  57. Hayashi H, Kimura M, Yoshimoto N et al. A case of HER2-positive male breast cancer with lung metastases showing a good response to trastuzumab and paclitaxel treatment. Breast Cancer 2009; 16: 136-40.
  58. Clarke M, Collins R, Darby S et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005; 366: 2087-106.
  59. Cutuli B, Cohen-Solal le Nir C, Lafontan de B et al. Breast - conserving therapy for ductal carcinoma in situ of the breast: the French Cancer Centers' experience. Int J Radiat Oncol Biol Phys 2002; 53: 868-79.
  60. Chakravarthy A, Kim C.R. Post - mastectomy radiation in male breast cancer. Radiother Oncol 2002; 65: 99-103.
  61. Jaiyesimi I.A, Buzdar A.U, Sahin A.A et al. Carcinoma of the male breast. Ann Intern Med 1992; 117: 771-7.
  62. Patel H.Z, Buzdar A.U, Hortobagyi G.N. Role of adjuvant chemotherapy in male breast cancer. Cancer 1989; 64: 1583-5.
  63. Nahleh Z.A. Hormonal therapy for male breast cancer: a different approach for a different disease. Cancer Treat Rev 2006; 32: 101-5.
  64. Lopez M, Di Lauro L, Lazzaro B et al. Hormonal treatment of disseminated male breast cancer. Oncology 1985; 42: 345-9.
  65. Xia Q, Shi Y.X, Liu D.G et al. Clinicopathological characteristics of male breast cancer: analysis of 25 cases at a single institution (in Chinese with English abstract). Nan Fang Yi Ke Da Xue Xue Bao 2011; 31: 1469-73.
  66. O'Malley C.D, Prehn A.W, Shema S.J et al. Racial/ethnic differences in survival rates in a population - based series of men with breast carcinoma. Cancer 2002; 94: 2836-43.

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