Efficacy and safety of pemetrexed maintenance therapy in advanced non-small-cell lung cancer: a review of phase III studies


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In Russia, over 57,000 new cases of malignant tumors of the trachea, bronchi, and lung were diagnosed in 2009, accounting for 19,8% of all cancers in men and 3,9% of all cancers in women. For most patients in Russia, these cancers are detected at a late stage (stage III – 32,4% and stage IV – 36,0%). Administration of maintenance therapy is one strategy to prolong response or the length of stable disease, resulting in improved survival for patients whose disease has not progressed after first-line induction therapy. This review will summarize the results of phase 3 studies of pemetrexed as maintenance therapy in advanced non-small cell lung cancer.

作者简介

O Kit

Ростовский научно-исследовательский онкологический институт

д-р мед. наук, проф., дир. РНИОИ

L Vladimirova

Ростовский научно-исследовательский онкологический институт

д-р мед. наук, проф., руководитель отд-ния химиогормонотерапии РНИОИ

E Sholokhova

Эли Лилли Восток С.А., Российское представительство, Москва

Email: Sholokhova_Evgeniya@lilly.com
мед. советник

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