Rituksimab pri lechenii autoimmunnykh tsitopeniy Obzor literatury


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В последние годы ритуксимаб стал применяться при аутоиммунных процессах: ревматоидном артрите, болезни Шёгрена, системной красной волчанке (СКВ), антифосфолипидном синдроме, аутоиммунных цитопениях и т.д. Механизм действия ритуксимаба при аутоиммунных болезнях основан не только на уменьшении количества В-лимфоцитов и уровня IgG, но и на снижении экспрессии CD40 и CD80 на В-лимфоцитах, что тормозит активацию Т-лимфоцитов. Ритуксимаб может индуцировать элиминацию аутореактивных Т-лимфоцитов и восстанавливать аутотолерантность.

作者简介

L Filatov

Клинико-диагностический центр, Екатеринбург

A Pivnik

ЦИУ Медико-хирургический центр им. Н.И.Пирогова, Москва

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