Znachenie taksanov v neoad\"yuvantnoy terapii raka molochnoy zhelezy

  • 作者: Bozhok A1, Semiglazov V1, Kletsel' A2, Arzumanov A3, Ivanova O1, Semiglazov V4
  • 隶属关系:
    1. ГУН НИИ онкологии им. проф. Н.Н.Петрова, Санкт-Петербург
    2. Клиника онкологии и гинекологии, Оснабрюк, Германия
    3. Центральный научно-исследовательский рентгенорадиологический институт, Санкт-Петербург
    4. Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова
  • 期: 卷 7, 编号 1 (2005)
  • 页面: 10-13
  • 栏目: Articles
  • URL: https://journals.rcsi.science/1815-1434/article/view/26569
  • ID: 26569

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Современный подход к лечению местно-распространенного РМЖ состоит в последовательном назначении системной терапии и местно-регионального воздействия. Анализ результатов нескольких неконтролируемых исследований показал, что первичная химиотерапия как индукционное лечение значительно увеличивает безрецидивный период и общую выживаемость у больных местно-распространенным РМЖ. Успехи первичной химиотерапии при местно-распространенном РМЖ не вызывают сомнений, однако целесообразность ее использования при ранних операбельных формах заболевания все еще является предметом дискуссий. Результаты продолжающихся исследований очень важны для понимания значения таксанов в неоадъювантной терапии РМЖ. Непосредственная эффективность таксанов достаточно высока и имеющиеся результаты рандомизированных исследований позволяют уже сегодня использовать комбинации таксанов и антрациклинов на предоперационном этапе в клинической практике. Проследив отдаленные результаты различных вариантов лечения, мы сможем понять, приводит ли использование таксанов к увеличению общей и безрецидивной выживаемости, какие комбинации и режимы введения наиболее эффективны, существуют ли определенные группы больных, у которых адъювантная и неоадъювантная терапия таксанами наиболее оправдана. Поскольку возможность излечения РМЖ основывается на адекватном хирургическом вмешательстве и эффективной системной терапии, результаты продолжающихся рандомизированных исследований III фазы очень важны для определения стандартов лечения.

关键词

作者简介

A Bozhok

ГУН НИИ онкологии им. проф. Н.Н.Петрова, Санкт-Петербург

V Semiglazov

ГУН НИИ онкологии им. проф. Н.Н.Петрова, Санкт-Петербург

A Kletsel'

Клиника онкологии и гинекологии, Оснабрюк, Германия

A Arzumanov

Центральный научно-исследовательский рентгенорадиологический институт, Санкт-Петербург

O Ivanova

ГУН НИИ онкологии им. проф. Н.Н.Петрова, Санкт-Петербург

V Semiglazov

Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова

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