News in immunotherapy for metastatic melanoma: prolgolimab in clinical practice (authors' experience)
- 作者: Oganesyan L.1,2, Karnaukhov N.2, Feoktistova P.2
-
隶属关系:
- Russian Medical Academy of Continuous Professional Education
- Loginov Moscow Clinical Scientific Center
- 期: 卷 25, 编号 3 (2023)
- 页面: 325-328
- 栏目: CLINICAL ONCOLOGY
- URL: https://journals.rcsi.science/1815-1434/article/view/148898
- DOI: https://doi.org/10.26442/18151434.2023.3.202382
- ID: 148898
如何引用文章
全文:
详细
The incidence of skin melanoma is growing globally and in Russia. Also, the proportion of patients with advanced skin melanoma prevails. Introduction into clinical practice of a novel group of immunological drugs (anti-CTLA4 and anti-PD-1) for metastatic melanoma increased the time to disease progression and patients' life expectancy. Prolgolimab is a PD-1 inhibitor, a new domestic drug that is effective and safe in treating metastatic melanoma. The article presents authors' experience with prolgolimab. When used in the first-line treatment of metastatic melanoma, this drug achieved long-term stabilization of the disease. The drug showed good tolerability, including in patients with severe comorbidity.
作者简介
Liana Oganesyan
Russian Medical Academy of Continuous Professional Education; Loginov Moscow Clinical Scientific Center
编辑信件的主要联系方式.
Email: liana15.94@mail.ru
ORCID iD: 0000-0001-7564-7472
graduate student, oncologist
俄罗斯联邦, MoscowNikolay Karnaukhov
Loginov Moscow Clinical Scientific Center
Email: editor@omnidoctor.ru
ORCID iD: 0000-0003-0889-2720
cand. sci. (med.)
俄罗斯联邦, MoscowPolina Feoktistova
Loginov Moscow Clinical Scientific Center
Email: editor@omnidoctor.ru
ORCID iD: 0000-0002-0340-7119
cand. sci. (med.)
俄罗斯联邦, Moscow参考
- Ali Z, Yousaf N, Larkin J. Melanoma epidemiology, biology and prognosis. EJC Suppl. 2013;11(2):81-91. doi: 10.1016/j.ejcsup.2013.07.012
- Харкевич Г.Ю., Демидов Л.В. Эффективность ниволумаба в лечении метастатической меланомы. Злокачественные опухоли. 2017;3:62-9 [Kharkevich GY, Demidov LV. Efficacy of nivolumab in advanced melanoma. Malignant Tumours. 2017;3:62-9 (in Russian)]. doi: 10.18027/2224-5057-2017-7-3-62-69
- The Global Cancer Observatory. December, 2020. Available at: https://gco.iarc.fr/today/fact-sheets-cancers. Accessed: 05.08.2023.
- Состояние онкологической помощи населению России в 2018 году. Под ред. А.Д. Каприна, В.В. Старинского, Г.В. Петровой. М.: МНИОИ им. П.А. Герцена − филиал ФГБУ «НМИЦ радиологии» Минздрава России, 2019 [Sostoianie onkologicheskoi pomoshchi naseleniiu Rossii v 2018 godu. Pod red. AD Kaprina, VV Starinskogo, GV Petrovoi. Moscow: MNIOI im. P.A. Gertsena − filial FGBU «NMITs radiologii» Minzdrava Rossii, 2019 (in Russian)].
- Орлова К.В., Федянин М.Ю., Симаненков К.Э., и др. Эффективность 1-й линии терапии пролголимабом у больных метастатической меланомой в реальной клинической практике: промежуточные результаты наблюдательного исследования FORA «FOrteca Real practice Assessment». Современная Онкология. 2022;24(4):413-25 [Orlova KV, Fedyanin M, Simanenkov KE, et al. Real-world efficacy of the first line therapy with prolgolimab in patients with metastatic melanoma: interim results of the FORA (FOrteca Real practice Assessment) observational study. Journal of Modern Oncology. 2022;24(4):413-25(in Russian)]. doi: 10.26442/18151434.2022.4.202035
- Румянцев А.Г., Тюляндин С.А. Эффективность ингибиторов контрольных точек иммунного ответа в лечении солидных опухолей. Практическая онкология. 2016;17(2):74-89 [Rumyantsev AA, Tjulandin SA. Efficacy of immune checkpoints inhibitors in the treatment of solid tumors. Prakticheskaya onkologiya = Practical Oncology. 2016;17(2):74-89 (in Russian)].
- Larkin J, Chiarion-Sileni V, Gonzalez R, et al. Five-year survival with combined nivolumab and ipilimumab in advanced melanoma. N Engl J Med. 2019;381(16):1535-46. doi: 10.1056/NEJMoa1910836
- Long GV, Atkinson V, Menzies AM, et al. A randomized phase II study of nivolumab or nivolumab combined with ipilimumab in patients (pts) with melanoma brain metastases (mets): the Anti-PD1 Brain Collaboration (ABC). J Clin Oncol. 2017; 35(15 suppl):9508. doi: 10.1200/JCO.2017.35.15_suppl.9508
- Robert C, Long GV, Brady B, et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med. 2015;372(4):320-30. doi: 10.1056/NEJMoa1412082
- Weber JS, Gibney G, Sullivan RJ, et al. Sequential administration of nivolumab and ipilimumab with a planned switch in patients with advanced melanoma (CheckMate 064): An open-label, randomised, phase 2 trial. Lancet Oncol. 2016;17(7):943-55. doi: 10.1016/S1470-2045(16)30126-7
- Строяковский Д.Л. Клиническое исследование MIRACULUM: результаты эффективности пролголимаба при метастатической меланоме на протяжении 3 лет наблюдения. Петербургский международный онкологический форум «Белые ночи». 2021 [Stroiakovskii D.L. Klinicheskoe issledovanie MIRACULUM: rezul'taty effektivnosti prolgolimaba pri metastaticheskoi melanome na protiazhenii 3 let nabliudeniia. Peterburgskii mezhdunarodnyi onkologicheskii forum «Belye nochi». 2021 (in Russian)].
- Tjulandin SA, Fedyanin M, Demidov LV, et al. Final results of phase II trial (MIRACULUM) of the novel PD-1 inhibitor prolgolimab in patients with advanced melanoma. Annals of Oncology. 2019;30:xi44. doi: 10.1093/annonc/mdz451.027
- Tjulandin S, Demidov L, Moiseyenko V, et al. Novel PD-1 inhibitor prolgolimab: expanding nonresectable/metastatic melanoma therapy choice. Eur J Cancer. 2021;149:222-32. doi: 10.1016/j.ejca.2021.02.030