Experience with olaparib in the treatment of BRCA-associated tumors in real clinical practice. Observational study

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Background. PARP inhibitor olaparib shows encouraging results in the treatment of patients with BRCA-associated tumors. The detection of new tumors associated with abnormalities of the BRCA gene, also can lead to the expansion of PARP inhibitors application. The application of PARP inhibitors improved treatment outcomes for ovarian, breast, prostate and pancreatic cancers in comparison with standard drug therapy regimens, demonstrating the moderate toxicity profile. All this makes olaparib the significant option in planning the tactics of treatment of this category of patients.

Aim. Assess the efficacy of olaparib in real clinical practice conditions in our region and to demonstrate the clinical experience accumulated in the regional clinical oncology dispensary.

Materials and methods. We analyzed the cases of the treatment with olaparib in the Republican Clinical Oncological Dispensary of the Ministry of Health of the Republic of Bashkortostan. The study included 79 patients.

Results. Median progression-free survival reached 12 months and the best response was the stabilization of the disease among patients receiving olaparib. Median progression-free survival was 6 months and the best response was the stabilization of the disease among the patients treated with olaparib during Re-Challenge regimen.

Conclusion. Olaparib applying in real clinical practice demonstrated satisfactory results.

作者简介

Alexander Sultanbaev

Republican Clinical Oncological Dispensary

编辑信件的主要联系方式.
Email: rkodrb@yandex.ru
ORCID iD: 0000-0003-0996-5995

Cand. Sci. (Med.)

俄罗斯联邦, Ufa

Konstantin Menshikov

Republican Clinical Oncological Dispensary; Bashkir State Medical University

Email: kmenshikov80@bk.ru
ORCID iD: 0000-0003-3734-2779

Cand. Sci. (Med.)

俄罗斯联邦, Ufa; Ufa

Shamil Musin

Republican Clinical Oncological Dispensary

Email: rkodrb@yandex.ru
ORCID iD: 0000-0003-1185-977X

Cand. Sci. (Med.)

俄罗斯联邦, Ufa

Ainur Nasretdinov

Republican Clinical Oncological Dispensary

Email: rkodrb@yandex.ru
ORCID iD: 0000-0001-8340-7962

onсologist

俄罗斯联邦, Ufa

Alfiya Fatikhova

Republican Clinical Oncological Dispensary

Email: rkodrb@yandex.ru
ORCID iD: 0000-0001-7821-0188

оnсologist

俄罗斯联邦, Ufa

Adel Izmailov

Republican Clinical Oncological Dispensary; Bashkir State Medical University

Email: izmailov75@mail.ru
ORCID iD: 0000-0002-8461-9243

D. Sci. (Med.)

俄罗斯联邦, Ufa; Ufa

Oleg Lipatov

Bashkir State Medical University

Email: lipatovoleg@bk.ru
ORCID iD: 0000-0002-8867-504X

D. Sci. (Med.)

俄罗斯联邦, Ufa

Rustam Ayupov

Republican Clinical Oncological Dispensary

Email: ru2003@bk.ru
ORCID iD: 0000-0002-6769-7194

Cand. Sci. (Med.)

俄罗斯联邦, Ufa

Nadezda Sultanbaeva

Republican Clinical Oncological Dispensary

Email: nd.sultan@rambler.ru
ORCID iD: 0000-0001-5926-0446

onсologist

俄罗斯联邦, Ufa

Irina Menshikova

Bashkir State Medical University

Email: menshikova@bk.ru
ORCID iD: 0000-0002-8665-8895

Cand. Sci. (Med.)

俄罗斯联邦, Ufa

Grigorii Serebrennikov

Bashkir State Medical University

Email: g.serebrennikov@mail.ru
ORCID iD: 0000-0002-7082-0085

Resident

俄罗斯联邦, Ufa

参考

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2. Fig. 1. Kaplan–Meier curve of progression-free survival (PFS) for patients applying olaparib.

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3. Fig. 2. Kaplan–Meier curves of PFS for patients applying olaparib in different lines, log-rank p-value 0.001.

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4. Fig. 3. Kaplan-Meier curve of PFS for patients applying olaparib as the Re-Challenge regimen.

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