Новые возможности химиотерапии антрациклин-таксанрезистентного рака молочной железы


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Аннотация

Обзор посвящен химиотерапии интенсивно предлеченного метастатического рака молочной железы. Рассмотрены возможные причины развития антрациклин - и таксан-резистентности, особенности механизма действия эпотилонов, приведены данные об эффективности различных цитостатиков. Обсуждены результаты клинических исследований иксабепилона, демонстрирующие высокую эффективность препарата в монорежиме или в комбинации с капецитабином при резистентности к таксанам и антрациклинам.

Об авторах

Елена Владимировна Артамонова

ФГБУ РОНЦ им. Н.Н.Блохина РАМН, Москва

д-р мед. наук, вед. науч. сотр. отд-ния изучения новых противоопухолевых лекарств

Людмила Валентиновна Манзюк

ФГБУ РОНЦ им. Н.Н.Блохина РАМН, Москва

д-р мед. наук, проф., зав. отд-нием изучения новых противоопухолевых лекарств

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© ООО "Консилиум Медикум", 2013

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