Treatment of advanced small cell lung cancer. Clinical case and literature review

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Abstract

Lung cancer is one of the most common tumors in humans. The incidence is in one of the leading positions. In 2019 1327 patients with this pathology were identified in the Republic of Bashkortostan. Of these, with stage III of the disease – 28.7%, with stage IV 45.8%, which is higher. Small cell lung cancer (SCLC) is one of the most prognostically unfavorable malignant tumors in humans. About 15% of lung tumors are SCLC. The first combination for the treatment of advanced SCLC after etoposide and platinum preparations was the combination of the etoposide + carboplatin (EP) regimen with atezolizumab. In the IMpower133 study, after a median follow-up of 13.9 months. median overall survival in the atezolizumab group was 12.3 months, and in the placebo group – 10.3 months. In clinical observation, the effectiveness of the combination of the EP regimen with atezolizumab has been demonstrated. A patient with SCLC received 4 courses of EP therapy with atezolizumab and 14 injections of atezolizumab. The partial response achieved is retained. Case study efficacy and satisfactory safety profile of the combination of atezolizumab and the EP regimen.

About the authors

Konstantin V. Menshikov

Republican Clinical Oncological Dispensary; Bashkir State Medical University

Author for correspondence.
Email: kmenshikov80@bk.ru
ORCID iD: 0000-0003-3734-2779

Cand. Sci. (Med.)

Russian Federation, Ufa; Ufa

Aleksandr V. Sultanbaev

Republican Clinical Oncological Dispensary

Email: rkodrb@yandex.ru
ORCID iD: 0000-0003-0996-5995

Cand. Sci. (Med.)

Russian Federation, Ufa

Shamil I. Musin

Republican Clinical Oncological Dispensary

Email: kmenshikov80@bk.ru
ORCID iD: 0000-0003-1185-977X

Cand. Sci. (Med.)

Russian Federation, Ufa

Irina A. Menshikova

Bashkir State Medical University

Email: i-menshikova@bk.ru
ORCID iD: 0000-0002-8665-8895

Cand. Sci. (Med.)

Russian Federation, Ufa

Ainur F. Nasretdinov

Republican Clinical Oncological Dispensary

Email: rkodrb@yandex.ru
ORCID iD: 0000-0001-8340-7962

onсologist

Russian Federation, Ufa

Nadezda I. Sultanbaeva

Republican Clinical Oncological Dispensary

Email: nd.sultan@rambler.ru
ORCID iD: 0000-0001-5926-0446

onсologist

Russian Federation, Ufa

References

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Supplementary files

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2. Fig. 1. Lung cancer stages diagram in the Republic of Bashkortostan in 2019 (%).

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3. Fig. 2. Median overall survival. One-year survival rate of 51.9% in the immunotherapy + chemotherapy group [21].

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4. Fig. 3. One-year progression-free survival rate of 12.6% [19].

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5. Fig. 4. PET/CT before the start of therapy (03.11.2019): a – in the frontal projection, b – in the lateral projection.

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6. Fig. 5. PET/CT after 4 courses of therapy (15.02.2020). Partial answer.

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