Radiation therapy in treatment of Rosai–Dorfman disease: literature review and report of a patient with cutaneous form

Cover Page

Cite item

Full Text

Abstract

Rosai–Dorfman disease (RDD) is a rare variant of the nonlangergans histiocytosis. Various presentation, systemic and localised forms and limited publications make diagnostics and prompt management difficult.

Aim. Literature review and presentation of the patient with cutaneous form of RDD.

Results. The patient is a 56 y.o male. In October 2019 he noticed a tumour in the left temporal area. After 3 weeks the tumor was removed. During the next two weeks the tumour recurred within the post-operative scar. After the review of the specimen and staging the skin form Rosai–Dorfman disease was diagnosed. Irradiation (total dose 36 Gr) was conducted. The tumor lessened. Through the next 4 months response is stable.

Сonclusion. Radiation therapy as a second line of treatment of the skin RDD led to a stable response.

About the authors

Vsevolod G. Potapenko

Municipal Clinical Hospital №31; Pavlov First Saint Petersburg State Medical University

Author for correspondence.
Email: potapenko.vsevolod@mail.ru
ORCID iD: 0000-0003-2985-0503

Cand. Sci. (Med.)

Russian Federation, Saint Petersburg

Irena E. Belousova

Kirov Military Medical Academy

Email: irena.belousova@mail.ru
ORCID iD: 0000-0002-4374-4435

D. Sci. (Med.), Prof.

Russian Federation, Saint Petersburg

Julia N. Vinogradova

Granov Russian Research Center for Radiology and Surgical Technologies

Email: winogradova68@mail.ru
ORCID iD: 0000-0002-0938-5213

D. Sci. (Med.)

Russian Federation, Saint Petersburg

Karina A. Kelehsaeva

Granov Russian Research Center for Radiology and Surgical Technologies

Email: kaloeva1972@yandex.ru
ORCID iD: 0000-0001-9001-266X

radiation therapist

Russian Federation, Saint Petersburg

Andrey M. Ulitin

Granov Russian Research Center for Radiology and Surgical Technologies

Email: andreiulitin000@gmail.com
ORCID iD: 0000-0003-2416-1258

Resident

Russian Federation, Saint Petersburg

Irina O. Smirnova

Municipal Hospital of Venerological and Skin Diseases; Saint Petersburg State University

Email: driosmirnova@yandex.ru

D. Sci. (Med.), Prof.

Russian Federation, Saint Petersburg

Yanina G. Petunova

Municipal Hospital of Venerological and Skin Diseases; Saint Petersburg State University

Email: yaninapetunova@yandex.ru
ORCID iD: 0000-0002-6489-4555

Cand. Sci. (Med.)

Russian Federation, Saint Petersburg

Nikolay V. Ilyin

Granov Russian Research Center for Radiology and Surgical Technologies

Email: ilyin_prof@mail.ru
ORCID iD: 0000-0002-8422-0689

D. Sci. (Med.), Prof.

Russian Federation, Saint Petersburg

References

  1. Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy. A newly recognized benign clinicopathological entity. Arch Pathol 1969; 87 (1): 63–70.
  2. Emile JF, Abla O, Fraitag S et al. Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood 2016; 127 (22): 2672–81. doi: 10.1182/blood-2016-01-690636
  3. Foucar E, Rosai J, Dorfman R. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity. Semin Diagn Pathol 1990; 7 (1): 19–73.
  4. Должанский О.В., Пальцева Е.М., Морозова М.М. и др. Солитарная эпителиоидная гемангиоэндотелиома в сочетании с нодулярным паренхиматозным амилоидозом легкого и болезнью Розаи–Дорфмана. Архив патологии. 2018; 80 (2): 52–9. [Dolzhanskiy O.V., Pal’tseva Ye.M., Morozova M.M. et al. Solitary epithelioid hemangioendothelioma in combination with nodular parenchymal amyloidosis of the lung and Rosai–Dorfman’s disease. Archiv of Patology. 2018; 80 (2): 52–9 (In Russ).]
  5. Haroche J, Charlotte F, Arnaud L et al. High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses. Blood 2012; 120 (13): 2700–3.
  6. Chakraborty R, Hampton OA, Shen X et al. Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis. Blood 2014; 124 (19): 3007–15.
  7. Pulsoni A, Anghel G, Falcucci P et al. Treatment of sinus histiocytosis with massive lymphadenopathy (Rosai–Dorfman disease): report of a case and literature review. Am J Hematol 2002; 69 (1): 67–71.
  8. Abla O, Jacobsen E, Picarsic J et al. Consensus recommendations for the diagnosis and clinical management of Rosai–Dorfman–Destombes disease. Blood 2018; 131 (26): 2877–90.
  9. Меликян А.Л. Синусный гистиоцитоз с массивной лимфаденопатией (болезнь Розаи–Дорфмана). Обзор литературы и случай из практики. Клин. онкогематология. 2008; 1 (3): 252–8. [Melikyan A.L. Sinus histiocytosis with massive lymphadenopathy (Rosai–Dorfman disease). Literature review and case from practice. Clin Oncohematol. 2008; 1 (3): 252–8 (In Russian).]
  10. Sathyanarayanan V, Issa A, Pinto R et al. Rosai–Dorfman disease: the MD Anderson cancer center experience. Clin Lymphoma Myeloma Leuk 2019; 19 (11): 709–14.
  11. Al-Khateeb TH. Cutaneous Rosai–Dorfman disease of the face: a comprehensive literature review and case report. J Oral Maxillofac Surg. 2016; 74 (3): 528–40.
  12. Ян C., Гветадзе Ш.Р., Илькаев К.Д. и др. Экстранодальная интраоссальная болезнь Розаи–Дорфмана в области нижней челюсти: описание клинического случая и обзор литературы. Опухоли головы и шеи. 2018; 8 (2): 34–8. doi: 10.17650/2222-1468-2018-8-2-34-38 [Yan C., Gvetadze S.R., Il’kayev K.D. et al. Extranodal intraosseous Rozai–Dorfman disease in the mandible: a description of a clinical case and a review of the literature. Head and Nick Tumors. 2018; 8 (2): 34–8. doi: 10.17650/2222-1468-2018-8-2-34-38 (in Russian).]
  13. Goyal G, Ravindran A, Young JR et al. Clinicopathological features, treatment approaches, and outcomes in Rosai–Dorfman disease. Haematologica 2020; 105 (2): 348–57. doi: 10.3324/haematol.2019.219626
  14. Kutlubay Z, Bairamov O, Sevim A et al. Rosai–Dorfman disease: a case report with nodal and cutaneous involvement and review of the literature. Am J Dermatopathol 2014; 36 (4): 353–7. doi: 10.1097/DAD.0b013e31829e5564
  15. James WD, Berger T, Elston D. Cutaneous lymphoid hyperplasia, cutaneous T-cell lymphoma, other malignant lymphomas, and allied diseases. Andrews’ Diseases of the Skin, Clinical Dermatology. 9th ed. Philadelphia: WB Saunders Company, 2019; p. 918–42.
  16. Picarsic J, Jaffe R. Pathology of histiocytic neoplasms and related disorders. In: Abla O, Janka G. Histiocytic Disorders. Zurich, Switzerland: Springer International Publishing, 2018; p. 3–50.
  17. Diamond EL, Dagna L, Hyman DM et al. Consensus guidelines for the diagnosis and clinical management of Erdheim–Chester disease. Blood 2014; 124 (4): 483–92.
  18. Ковригина А.М. Морфологическая характеристика реактивных изменений лимфоузлов. Клин. онкогематология. 2009; 2 (4): 297–305. [Kovrigina A.M. Morphological characteristics of lymph node reactive changes. Clin Oncohematol. 2009; 2 (4): 297–305 (in Russian).]
  19. Швец О.А., Абрамов Д.С., Хорева А.Л. и др. Лимфаденопатия по типу болезни Розаи–Дорфмана у пациента с синдромом Вискотта–Олдрича: сложности диагностики. Вопр. гематологии/онкологии и иммунопатологии в педиатрии. 2020; 19 (1): 108–15. [Shvets O.A., Abramov D.S., Khoreva A.L. et al. Rosay–Dorfman – like lymphadenopathy in a patient with Wiskott–Aldrich syndrome: diagnostic difficulties. Pediatric Hematology/Oncology and Immunopathology. 2020; 19 (1): 108–15 (in Russian).]
  20. Потапенко В.Г., Леенман Е.Е., Потихонова Н.А. и др. Лихорадка, ассоциированная с металлоконструкцией. Клиническое наблюдение. Журн. инфектологии. 2019; 12 (3): 126–9. doi: 10.22625/2072-6732-2019-11-3-126-130 [Potapenko V.G., Leyenman Ye.Ye., Potikhonova N.A. et al. Fever associated with hardware. Clinical observation. J Infectol. 2019; 12 (3): 126–9. doi: 10.22625/2072-6732-2019-11-3-126-130 (in Russian).]
  21. Vaamonde R, Cabrera JM, Vaamonde-Martin RJ et al. Silicone granulomatous lymphadenopathy and siliconomas of the breast. Histol Histopathol 1997; 12: 1003–11.
  22. Knösel T, Meisel H, Borgmann A et al. Parvovirus B19 infection associated with unilateral cervical lymphadenopathy, apoptotic sinus histiocytosis, and prolonged fatigue. J Clin Pathol 2005; 58 (8): 872–5. doi: 10.1136/jcp.2004.022756
  23. Соколовский Е.В., Михеев Г.Н., Рыбакова М.Г. и др. Синусный гистиоцитоз кожи лица нелангергансового типа (кожная форма болезни Розаи–Дорфмана). Вестн. дерматологии и венерологии. 2018; 94 (5): 66–71. doi: 10.25208/0042-4609-2018-94-5-66-71 [Sokolovskiy Ye.V., Mikheyev G.N., Rybakova M.G. et al. Sinus histiocytosis of the skin of the face of the nonlangerganic type (cutaneous form of Rosai–Dorfman disease). Vestnik dermatologii i venerologii. 2018; 94 (5): 66–71. doi: 10.25208/0042-4609-2018-94-5-66-71 (In Russian).]
  24. Jordan MB, Hult A, Filipovich A. Histiocytic Disorders. In: Hematology: Basic Principles and Practice. Elsevier Inc., 2018.
  25. Потекаев Н.Н., Львов А.Н., Бобко С.И. и др. Кожная форма болезни Розаи–Дорфмана. Клин. дерматология и венерология. 2017; 16 (1): 30–9. doi: 10.17116/klinderma201716130-38 [Potekayev N.N., Lvov A.N., Bobko S.I. et al. Cutaneous form of Rosai–Dorfman disease. Rus J Clin Dermatol Venerol. 2017; 16 (1): 30–9. doi: 10.17116/klinderma201716130-38 (In Russian).]
  26. Chen HH, Zhou SH, Wang SQ et al. Factors associated with recurrence and therapeutic strategies for sinonasal Rosai–Dorfman disease. Head Neck 2011; 34 (10): 1504–13. doi: 10.1002/hed.21832
  27. Ferry JA, Klepeis V, Sohani AR et al. IgG4-related Orbital Disease and Its Mimics in a Western Population. Am J Surg Pathol 2015; 39 (12): 1688–700. doi: 10.1097/PAS.0000000000000497
  28. Tsang WY, Chan JK, Ho WK et al. Extranodal Rosai–Dorfman disease: an uncommon cause of persistent nodule in the ear. J Laryngol Otol 1992; 106 (3): 249–51. doi: 10.1017/s0022215100119188
  29. Andriko JA, Morrison A, Colegial CH et al. Rosai–Dorfman disease isolated to the central nervous system: a report of 11 cases. Mod Pathol 2001; 14 (3): 172–8. doi: 10.1038/modpathol.3880278
  30. Forest F, N’guyen AT, Fesselet J et al. Meningeal Rosai–Dorfman disease mimicking meningioma. Ann Hematol 2014; 93 (6): 937–40. doi: 10.1007/s00277-013-1994-8

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1. Diffuse dermal infiltration mostly with large histiocytes (insertion), giant cells, few plasma cells, clusters of lymphocytes.

Download (1MB)
Indexing metadata
3. Fig. 2. Expression of S100 by the histiocytic cells.

Download (1MB)
Indexing metadata
4. Fig. 3. Expression of CD163 by the histiocytic cells.

Download (1MB)
Indexing metadata
5. Fig. 4. Lymphocytes and neutrophils (pointed by arrows) in the cytoplasm of histiocytes (S100+) cells (emperiopolesis).

Download (647KB)
Indexing metadata
6. Fig. 5. Patient with Rosai–Dorfman disease with involvement of skin in temporal, buccal, forehead, mandibular and scalp areas.

Download (544KB)
Indexing metadata
7. Fig 6. Patient with Rosai–Dorfman disease with involvement of skin in temporal, buccal, forehead, mandibular and scalp areas following 3 months after the radiotherapy course.

Download (370KB)
Indexing metadata

Copyright (c) 2020 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies