The role of bevacizumab in the treatment of patients with ovarian and cervical cancer


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Abstract

The development of cytostatic therapy in the treatment of ovarian and cervical cancer has resulted in a deadlocked situation. Thus, the basic aim of the investigations was to examine the biological basis of these diseases, last years. Angiogenesis is one of the main factors of the tumor microenvironment, associated with tumor growth and metastasis. In this regard, new drugs that work by inhibiting angiogenesis have started to appear. One of the first drugs studied in randomized phase III studies was bevacizumab. The application of bevacizumab demonstrated the significant increase both in progression free-survival and life expectancy in high-risk group of patients with ovarian cancer and in patients with recurrent and advanced cervical cancer.

About the authors

S V Khokhlova

N.N.Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation

д-р мед. наук, ст. науч. сотр. отд-ния химиотерапии ФГБУ «РОНЦ им.Н.Н.Блохина» 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

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