Prospective analysis of efficacy and safety of BR regime in the first-line treatment of chronic lymphocytic leukemia


Cite item

Full Text

Abstract

This trial has evaluated a systematic prospective analysis of the efficacy and safety of BR in CLL patients in the routine clinical practice. It included 179 patients with verified CLL diagnosis and the presence of the indications for initiation of therapy according to the guidelines iwCLL who received BR regimen. The trial has shown that BR regime has high efficiency and relatively low toxicity in first line therapy of CLL and also is well tolerated in patients with comorbidity and impaired renal function. The efficiency of BR is lower in patients with IGHV-unmutated type of CLL. The achieving of the eradication of MRD in BM is the best predictor of PFS.

About the authors

E A Stadnik

V.A.Almazov North-West Federal Medical Research Center of the Ministry of Health of the Russian Federation; I.P.Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation

Email: elena_stadnik@mail.ru
канд. мед. наук, ФГБОУ ВО Первый СПбГМУ им. И.П.Павлова, доц., ст. науч. сотр. ФГБУ СЗФМИЦ им. В.А.Алмазова 197341, Russian Federation, Saint Petersburg, ul. Akkuratova, d. 2; 197022, Russian Federation, Saint Petersburg, ul. L'va Tolstogo, d. 6/8

V V Strugov

V.A.Almazov North-West Federal Medical Research Center of the Ministry of Health of the Russian Federation

197341, Russian Federation, Saint Petersburg, ul. Akkuratova, d. 2

T O Andreeva

V.A.Almazov North-West Federal Medical Research Center of the Ministry of Health of the Russian Federation

197341, Russian Federation, Saint Petersburg, ul. Akkuratova, d. 2

Yu V Virts

V.A.Almazov North-West Federal Medical Research Center of the Ministry of Health of the Russian Federation

197341, Russian Federation, Saint Petersburg, ul. Akkuratova, d. 2

Yu V Mirolyubova

V.A.Almazov North-West Federal Medical Research Center of the Ministry of Health of the Russian Federation

197341, Russian Federation, Saint Petersburg, ul. Akkuratova, d. 2

P A Butylin

V.A.Almazov North-West Federal Medical Research Center of the Ministry of Health of the Russian Federation

197341, Russian Federation, Saint Petersburg, ul. Akkuratova, d. 2

A Yu Zaritskiy

V.A.Almazov North-West Federal Medical Research Center of the Ministry of Health of the Russian Federation

д-р мед. наук, проф. ФГБУ СЗФМИЦ им. В.А.Алмазова, дир. Института гематологии 197341, Russian Federation, Saint Petersburg, ul. Akkuratova, d. 2


Copyright (c) 2016 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies