A population-based portrait of breast cancer in russia: a cancer register-based analysis in russian

We shows the Russian Breast Cancer (BC) Register-based analysis, established under the auspices of the non-profit making partnership "Equal right to life" with the inclusion of 49784 BC patients under the examination and treatment in 18 cancer institutions of the Russian Federation between 1985 and 2014 years. Stage distribution in patients with BC, included in the Patient Register, is absolutely identical to the official statistics of malignant neoplasms in Russia (edited by A.D.Kaprin, 2014); it is the real situation in our country. BC early detection is not good enough in all regions of the RF: the proportion of non-invasive cancer (in situ) is less than 1% and stage I BC - 18,3% (15-26%). We have identified the important features of the population-based "portrait" of BC: women with advanced stages of BC (III andIV) are usually of old age in our country, but not the young one. It appears that, women older than 60 years do not participate in BC screening program and will visit the oncologist only when significant clinical symptoms of the disease are appeared. Stage I breast cancer has positive "biological" portrait: a high proportion of luminal HER2 negative subtype of cancer and the extremely low proportion of HER2+ subtypes; there are only 11,8% of patients suffering from stage I HER2+ breast cancer. Patients with locally advanced (stage III) and metastatic cancer (stage IV) have more aggressive forms of tumors; more than 40% of cancers are HER2+ and triple negative immunophenotype of BC. The modernization of BC early detection programs in the RF will not only help to improve the disease prognosis, but also to save spending on expensive medicines (cytostatic and targeted therapy) which are used for treatment in such cases.

russian women suffering from breast cancer, population-based analysis of breast cancer, breast cancer early detection, stage I breast cancer, biological subtypes of breast cancer