Radiation treatment of the primary vulvar Pagetʼs disease: case report


Cite item

Full Text

Abstract

We report a 69-year-old female patient with primary non-invasive isolated extra-mammary Pagetʼs disease of the vulva. EBRT resultedin full resorption of the lesion without auxiliary techniques, making EBRT to be considered as an alternative to surgery in some cases.

About the authors

E L Razumova

Department of Oncology, Russian Medical Academy of Postgraduate Education, Ministry of Health of Russia (125993, Barricadnaya st. 2/1, Russia, Moscow)

канд. мед. наук, доц. каф. радиологии

Yu E Kizhaev

Department of Oncology, Russian Medical Academy of Postgraduate Education, Ministry of Health of Russia (125993, Barricadnaya st. 2/1, Russia, Moscow)

канд. мед. наук

E A Ukolova

Department of Oncology, Russian Medical Academy of Postgraduate Education, Ministry of Health of Russia (125993, Barricadnaya st. 2/1, Russia, Moscow)

References

  1. AJCC Cancer Staging Manual. 7th ed. S.Edge, D.R.Byrd, C.C.Compton et al (Eds.). 2010, XV.
  2. Hashemi P, Kao G.F, Konia T et al. Multicentric primary extramammary Paget disease: a Toker cell disorder? Cutis 2014; 94 (1): 35-8.
  3. Fu Yao S. Pathology of the uterine cervix, vagina and vulva. 2nd ed. Philadelphia: Saunder, 2002.
  4. Lloyd J, Flanagan A.M. Mammary and extramammary Paget's disease. J Clin Pathol 2000; 53: 742-9.
  5. Moore D.H, Wui-Jin Koh, McGuire W.P, Wilkinson E.J. Vulva. In: Principles and practice of gynecologic oncology. 4th ed. Eds. W.J.Hoskins et al. Lippincott Williams&Wilkins, 2005.
  6. De Magnis A, Checcucci V, Catalano C et al. Vulvar paget disease: a large single - centre experience on clinical presentation, surgical treatment, and long - term outcomes. J Low Genit Tract Dis 2013; 17 (2): 104-10.
  7. Nomura H, Matoda M, Okamoto S, et al. Clinicopathologic Features and Treatment Outcomes of Primary Extramammary Paget Disease of the Vulva. J Low Genit Tract Dis 2014.
  8. Nardelli A.A, Stafinski T, Menon D. Effectiveness of photodynamic therapy for mammary and extra - mammary Paget's disease: a state of the science review. BMC Dermatol 2011; 11: 13.
  9. Edey K.A, Allan E, Murdoch J.B et al. Interventions for the treatment of Paget's disease of the vulva. Cochrane Database Syst Rev 2013; 10: CD009245.
  10. Hartman R, Chu J, Patel R et al. Extramammary Paget disease. Dermatol Online J 2011; 17 (10): 4.
  11. Besa P, Rich T.A, Delclos L et al. Extramammary Paget's disease of the perineal skin: role of radiotherapy. Int J Radiat Oncol Biol Phys 1992; 24 (1): 73-8.
  12. Carrozzo A.M, Cipriani C, Donati P et al. Dermo Beta Brachytherapy with 188Re in extramammary Paget's disease. G Ital Dermatol Venereol 2014; 149 (1): 115-21.
  13. Hata M, Omura M, Koike I et al. Role of radiotherapy as curative treatment of extramammary Paget's disease. Int J Radiat Oncol Biol Phys 2011; 80 (1): 47-54.
  14. Seok-Hyun Son, Jung-Seok Lee, Yeon-Sil Kim et al. The Role of Radiation Therapy for the Extramammary Paget's Disease of the Vulva; Experience of 3 Cases. Cancer Res Treat 2005; 37 (6): 365-9.
  15. Marcos S, Montero A, Capuz B et al. HDR-plesiotherapy for the treatment of anogenital extramammary Paget's disease. Rep Pract Oncol Radiother 2012; 17 (3): 163-7.
  16. Cai Y, Sheng W, Xiang L et al. Primary extramammary Paget's disease of the vulva: the clinicopathological features and treatment outcomes in a series of 43 patients. Gynecol Oncol 2013; 129 (2): 412-6.

Copyright (c) 2014 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies