Modern options in personalized therapy of metastatic cutaneous melanoma


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Abstract

A great progress was recently achieved in metastatic melanoma therapy. New targeted therapies allow high efficacy expectations for personalized treatment approaches. BRAF-inhibitors significantly increase time to progression, overall survival and response rate in malignant melanoma patients. Vemurafenib is the first registered in Russia drug of this type. Current clinical data review on vemurafenib is presented in this paper.

About the authors

S A Protsenko

ФГБУ Научно-исследовательский институт онкологии им. Н.Н.Петрова Минздрава России, Санкт-Петербург

д-р мед. наук, зав. отд-нием химиотерапии и инновационных технологий, вед. науч. сотр. отд. терапевтической онкологии

A V Novik

ФГБУ Научно-исследовательский институт онкологии им. Н.Н.Петрова Минздрава России, Санкт-Петербург; ГБОУ ВПО Санкт-Петербургская государственная педиатрическая медицинская академия Минздрава России

канд. мед. наук, ст. науч. сотр. отд-ния химиотерапии и инновационных технологий ФГБУ НИИ онкологии им. Н.Н.Петрова, доц. каф. онкологии с курсом лучевой диагностики и лучевой терапии ГБОУ ВПО СПб ГПМА

Z Yu Akhaeva

ФГБУ Научно-исследовательский институт онкологии им. Н.Н.Петрова Минздрава России, Санкт-Петербург

аспир. отд. терапевтической онкологии

A S Zhabina

ФГБУ Научно-исследовательский институт онкологии им. Н.Н.Петрова Минздрава России, Санкт-Петербург

канд. мед. наук, науч. сотр. отд-ния химиотерапии с паллиативной помощью

E N Imyanitov

ФГБУ Научно-исследовательский институт онкологии им. Н.Н.Петрова Минздрава России, Санкт-Петербург

д-р мед. наук, проф., рук. лаборатории молекулярной онкологии

A I Semenova

ФГБУ Научно-исследовательский институт онкологии им. Н.Н.Петрова Минздрава России, Санкт-Петербург

канд. мед. наук, науч. сотр. отд-ния химиотерапии и инновационных технологий

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