Diagnostic value of the NGAL in determining the functional state of the kidney after percutaneous nephrolithotomy
- Authors: Merinov D.S.1, Golovanov S.A.1, Gurbanov S.S.1, Artemov A.V.1, Shamkhalova K.K.1
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Affiliations:
- N.A. Lopatkin Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiologiсal Center
- Issue: No 4 (2024)
- Pages: 69-74
- Section: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1728-2985/article/view/264896
- DOI: https://doi.org/10.18565/urology.2024.4.69-74
- ID: 264896
Cite item
Abstract
Introduction. Percutaneous nephrolithotomy (PNL), being a minimally invasive procedure, is accompanied by damage to blood vessels and renal parenchyma and, as a consequence, impaired renal hemodynamics. In this work we determined the dynamics of the biomarker of acute kidney injury NGAL depending on the deficit of renal function on the ipsilateral side, the type of stone, the number of accesses, the duration of the procedure, and the initial level of NGAL.
Aim. To study the role of NGAL in determining the potential risks of renal parenchyma damage with PNL in adult patients with nephrolithiasis.
Materials and methods. A total of 46 patients in whom the serum concentration of NGAL was determined before and immediately after PNL, as well as 6, 12, 24 and 48 hours later, were included in the study. PNL was performed under endotracheal anesthesia in the prone position using the standard technique with a 24 Fr nephroscope. When creating an additional (more than one) access, a nephroscope with a 16.5 Fr access sheath was used.
Results. Our results showed that the functional state of the renal parenchyma depended to a greater extent on the initial deficit of more than 50% according to nuclear scintigraphy with staghorn stones of 3-4 types, and to a lesser extent on the duration of the procedures, the number of accesses and the presence of bacteriuria.
Conclusion. Determination of NGAL concentration can be a convenient test for assessing the impairment and restoration of the functional state of the renal parenchyma in the early stages after PNL.
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##article.viewOnOriginalSite##About the authors
D. S. Merinov
N.A. Lopatkin Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiologiсal Center
Email: gurbanovsh@gmail.com
ORCID iD: 0000-0001-5966-9233
PhD, MD, Head of the Department of Endourology
Russian Federation, MoscowS. A. Golovanov
N.A. Lopatkin Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiologiсal Center
Email: gurbanovsh@gmail.com
ORCID iD: 0000-0002-6516-4730
MD, Head of Group of Clinical and Laboratory Diagnostics of Scientific and Laboratory Department
Russian Federation, MoscowSh. Sh. Gurbanov
N.A. Lopatkin Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiologiсal Center
Author for correspondence.
Email: gurbanovsh@gmail.com
PhD, Leading Researcher at the Department of Endourology
Russian Federation, MoscowA. V. Artemov
N.A. Lopatkin Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiologiсal Center
Email: artie@mail.ru
PhD, Head of the Operating Theatre with Sterilization
Russian Federation, MoscowK. K. Shamkhalova
N.A. Lopatkin Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiologiсal Center
Email: kamila.shch@mail.ru
PhD Student
Russian Federation, MoscowReferences
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